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A total of 84 adults aged &lt;\u00a060\u00a0years with colorectal cancer were randomised to either an intervention group (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a042) receiving a 7\u2010session self\u2010led virtual reality\u2010based cognitive behavioral therapy or an attention control group (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a042) receiving regular health consultations. The sick role adaptation, illness perception, anxiety and depression, and coping modes were measured at baseline, 1\u2010month, 2\u2010month and 3\u2010month post\u2010intervention.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared to the controls, the intervention group had significantly higher level of sick role adaptation, more positive illness perception, less anxiety and depression, more adaptative coping modes adopted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The virtual reality\u2010based cognitive behavioral therapy enhanced adaptation to cancer in young and middle\u2010age patients with colorectal cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      The study was registered on 21 June, 2023 in Chinese Clinical Trial Registry (No.: ChiCTR2300072699) at\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.chictr.org.cn\/\">https:\/\/www.chictr.org.cn\/<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pon.70406","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T04:01:46Z","timestamp":1773979306000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of Virtual Reality\u2010Based Cognitive Behavioral Therapy on Sick Role Adaptation for Patients With Colorectal Cancer: A Randomised Controlled Trial"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2296-3014","authenticated-orcid":false,"given":"Xinxin","family":"Li","sequence":"first","affiliation":[{"name":"School of Medicine and Health Shunde Polytechnic University  Foshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5622-376X","authenticated-orcid":false,"given":"Xiaodan","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Sun Yat\u2010sen University Cancer Center  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caixia","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Sun Yat\u2010sen University Cancer Center  Guangzhou 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