{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T21:07:57Z","timestamp":1781557677996,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T00:00:00Z","timestamp":1774137600000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1178487"],"award-info":[{"award-number":["APP1178487"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016052","name":"Friends of The Mater Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Advances in cancer treatment have led to improved survival rates, but challenges related to health\u2010related quality of life (HRQoL) persist, often exacerbated by sleep disturbances. We present a pre\u2010registered, secondary analysis of HRQoL from a trial of sleep interventions among women with early or advanced breast cancer receiving chemotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>This 6\u2010week, multisite, remotely\u2010delivered, randomized controlled trial compared Cognitive Behavioral Therapy for Insomnia (CBT\u2010I), Bright Light Therapy (BLT), their combination (CBT\u2010I\u00a0+\u00a0BLT), and an active control (Sleep Hygiene Education, SHE) on HRQoL as measured by the PROMIS\u2010Preference score (anchors: 0 \u201cDead\u201d to 1 \u201cFull health\u201d) at baseline, mid\u2010point (3\u2010weeks), post\u2010intervention (6\u2010weeks), and follow\u2010ups (3&amp;6\u2010months). Interventions involved emails and tailored therapist\u2010assisted intervention sessions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      219 women receiving chemotherapy (\n                      <jats:italic>M<\/jats:italic>\n                      <jats:sub>age<\/jats:sub>\n                      50.67\u00a0years) were recruited. At baseline, average HRQoL was low (0.27). CBT\u2010I led to a significant improvement from baseline to post\u2010intervention (\n                      <jats:italic>b<\/jats:italic>\n                      \u00a0=\u00a00.06;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.012). In contrast, BLT showed no significant effects (all\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0\u2265\u00a00.519). No CBT\u2010I \u00d7 BLT interaction was observed (all\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0\u2265\u00a00.759). Clinically meaningful improvement (\u2265 MID) was observed in 71.2% of CBT\u2010I participants. Within\u2010group analyses from baseline to post\u2010intervention showed the largest HRQoL improvements in CBT\u2010I and CBT\u2010I\u00a0+\u00a0BLT groups (both b\u00a0=\u00a00.14;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001); smaller gains were observed in BLT and SHE groups (\n                      <jats:italic>b<\/jats:italic>\n                      \u00a0=\u00a00.07\u20130.09;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0\u2264\u00a00.024). No significant changes were observed in any group at 6\u2010month follow\u2010up (all\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0\u2265\u00a00.096). Exploratory analyses suggested benefits of BLT in patients with metastatic disease and greater insomnia severity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CBT\u2010I was associated with clinically meaningful improvements in HRQoL during chemotherapy. These findings support the integration of CBT\u2010I into supportive care and highlight the need for tailored approaches for patients with advanced disease or persistent insomnia symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>ACTRN12620001133921<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pon.70418","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T02:59:41Z","timestamp":1774234781000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Randomized Controlled Trial: Evaluating the Sleep, Cancer and Rest (SleepCaRe) Trial to Improve Health\u2010Related Quality of Life in Women Undergoing Chemotherapy for Breast Cancer"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8351-4231","authenticated-orcid":false,"given":"Rebecca","family":"Wallace","sequence":"first","affiliation":[{"name":"School of Psychological Sciences Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marliese","family":"Alexander","sequence":"additional","affiliation":[{"name":"Pharmacy Department Peter MacCallum Cancer Centre  Melbourne Australia"},{"name":"Sir Peter MacCallum Department of Oncology The University of Melbourne  Parkville Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daphne","family":"Day","sequence":"additional","affiliation":[{"name":"Department of Oncology Monash Health  Melbourne Australia"},{"name":"Department of Medicine, Nursing and Health Sciences Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Diggens","sequence":"additional","affiliation":[{"name":"People and Culture Peter MacCallum Cancer Centre  Melbourne Australia"},{"name":"Department of Psychology Psychosocial Oncology Program Peter MacCallum Cancer Centre  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Ftanou","sequence":"additional","affiliation":[{"name":"Department of Psychology Psychosocial Oncology Program Peter MacCallum Cancer Centre  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Aedo\u2010Lopez","sequence":"additional","affiliation":[{"name":"Department of Oncology Monash Health  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Bei","sequence":"additional","affiliation":[{"name":"School of Psychological Sciences Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Blum","sequence":"additional","affiliation":[{"name":"Department of Oncology Bendigo Cancer Centre Bendigo Health  Bendigo Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances","family":"Boyle","sequence":"additional","affiliation":[{"name":"Patricia Ritchie Centre for Cancer Care and Research Mater Hospital North Sydney Australia and University of Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trang Thuy","family":"Do","sequence":"additional","affiliation":[{"name":"School of Psychological Sciences Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prudence A.","family":"Francis","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Peter MacCallum Cancer Centre  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila N.","family":"Garland","sequence":"additional","affiliation":[{"name":"Department of Psychology Memorial University  St. John's Newfoundland and Labrador Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Maccora","sequence":"additional","affiliation":[{"name":"School of Psychological Sciences Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharad","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Ballarat Regional Integrated Cancer Centre Grampians Health  Ballarat Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley","family":"Stafford","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Melbourne  Melbourne Australia"},{"name":"Genomic Medicine and Parkville Familial Cancer Centre The Royal Melbourne Hospital  Parkville Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"White","sequence":"additional","affiliation":[{"name":"Department of Oncology Monash Health  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7211-6454","authenticated-orcid":false,"given":"Duncan","family":"Mortimer","sequence":"additional","affiliation":[{"name":"Centre for Health Economics Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0271-6702","authenticated-orcid":false,"given":"Joshua F.","family":"Wiley","sequence":"additional","affiliation":[{"name":"School of Psychological Sciences Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40273\u2010016\u20100389\u20109"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S47790"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/nss.s18895"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0277\u20109536(01)00043\u20100"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsaa070"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2001.19.3.895"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1269378"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2014.09.003"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/nss.s34846"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2015.07.001"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102296\u201013\u201040"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2022.101646"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/15402002.2011.634940"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2025.03.034"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/07420528.2021.1871914"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsab246"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2022.106877"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.879"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063\u2010018\u20102733\u20101"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djab223"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2019.02.004"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.04.011"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/0272989x18776637"},{"key":"e_1_2_11_26_1","unstructured":"PROPrScore. FAQs. \u201cFAQs \u2013 PROPr \u201d (2025): [cited 2025 May 13] https:\/\/www.proprscore.com\/faqs\/."},{"key":"e_1_2_11_27_1","volume-title":"R: A Language and Environment for Statistical Computing [Internet]","author":"R Core Team","year":"2020"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/10705511.2017.1402334"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3758\/s13428\u2010017\u20100976\u20105"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2020.101376"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.1981"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjspcare\u20102021\u2010003135"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136\u2010012\u20100243\u20102"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2021.09.010"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2016.01162"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764\u2010017\u20100597\u20100"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2007.13.9006"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/cmx122"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1159\/000502943"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1037\/hea0001497"}],"container-title":["Psycho-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pon.70418","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pon.70418","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pon.70418","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T17:22:53Z","timestamp":1774891373000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pon.70418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/pon.70418"],"URL":"https:\/\/doi.org\/10.1002\/pon.70418","archive":["Portico"],"relation":{},"ISSN":["1057-9249","1099-1611"],"issn-type":[{"value":"1057-9249","type":"print"},{"value":"1099-1611","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2025-11-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70418"}}