{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:36:11Z","timestamp":1791221771176,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Rising advanced cancer incidence globally places profound existential distress and psychological burden on family caregivers. We culturally adapted Meaning\u2010Centered Psychotherapy for Cancer Caregivers (MCP\u2010C) from Western to Chinese context, targeting existential distress through meaning\u2010making processes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This pilot randomized controlled trial aimed to examine the feasibility, acceptability, and preliminary effects of an online MCP\u2010C (eMCP\u2010C) among caregivers of patients with advanced cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Caregivers of patients with advanced cancer, experiencing distress related to caregiving, were randomly assigned (1:1) to eMCP\u2010C or enhanced usual care groups. Over 7\u00a0weeks, participants received weekly individual session of eMCP\u2010C focusing on meaning making and coping with caregiving, whereas enhanced usual care group received resources for mental health treatment and targeted referrals for specific distress problems. Feasibility outcomes were assessed through questionnaires and semi\u2010structured interviews at 7\u2010week. Efficacy outcomes were assessed by questionnaire at baseline, 7, and 19\u00a0weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Forty\u2010six caregivers enrolled (26\u201379\u00a0years old), among which thirty\u2010seven (80%) completed the study. Intervention attendance, retention rates, and participant satisfaction were satisfactory. Depression, anxiety, meaning, peace, and self\u2010esteem improved from baseline to immediate and 3\u2010month post\u2010intervention in intervention group. Qualitative analysis revealed three key therapeutic mechanisms: (1) Therapeutic Alliance as a Catalyst for Intrapersonal and Interpersonal Healing, (2) Meaning\u2010making Through Acceptance and Action, and (3) Empowering Through Affirmation and Self\u2010Determined Action.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>For Chinese caregivers of patients with advanced cancer, eMCP\u2010C is feasible, well\u2010accepted, and showed preliminary benefits in psychological distress, meaning, peace, and self\u2010esteem, compared to an enhanced usual care group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pon.70420","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T15:34:13Z","timestamp":1773156853000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of an Online Meaning\u2010Centered Psychotherapy in Caregivers of Advanced Cancer (eMCP\u2010C): A Mixed\u2010Method Pilot Randomized Controlled Trial"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2950-5251","authenticated-orcid":false,"given":"Naomi","family":"Takemura","sequence":"first","affiliation":[{"name":"School of Nursing The Hong Kong Polytechnic University  Hong Kong SAR China"},{"name":"JC STEM Lab of Digital Oncology Care Enhancement  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6211-9053","authenticated-orcid":false,"given":"Arthur Cheuk\u2010Man","family":"Li","sequence":"additional","affiliation":[{"name":"LKS Faculty of Medicine The University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9793-9273","authenticated-orcid":false,"given":"Wing Lok","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology LKS Faculty of Medicine The University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9359-1748","authenticated-orcid":false,"given":"Sau Fung","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Nursing LKS Faculty of Medicine The University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7000-1306","authenticated-orcid":false,"given":"Vivian Weiqun","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Social Work and Social Administration Faculty of Social Sciences The University of Hong Kong  Hong Kong SAR China"},{"name":"Sau Po Centre on Ageing The University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7365-9146","authenticated-orcid":false,"given":"Daniel Yee\u2010Tak","family":"Fong","sequence":"additional","affiliation":[{"name":"School of Nursing LKS Faculty of Medicine The University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica Kang Qi","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Nursing The Hong Kong Polytechnic University  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1344-5944","authenticated-orcid":false,"given":"Janelle","family":"Yorke","sequence":"additional","affiliation":[{"name":"School of Nursing The Hong Kong Polytechnic University  Hong Kong SAR China"},{"name":"JC STEM Lab of Digital Oncology Care Enhancement  Hong Kong SAR China"},{"name":"Division of Nursing Midwifery &amp; Social Work School of Health Sciences University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2140-5635","authenticated-orcid":false,"given":"Allison J.","family":"Applebaum","sequence":"additional","affiliation":[{"name":"Brookdale Department of Geriatrics and Palliative Medicine Steven S. 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