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Meaning in life (primary outcome), anxiety and depression, quality of life, existential wellbeing, and posttraumatic growth were measured at 2\u00a0months post randomization with follow\u2010up at 4 and 6\u00a0months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were no significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05) inter\u2010group differences in FACIT\u2010Sp\u201012 Meaning subscale scores 2\u00a0months post\u2010randomization in independent two\u2010sample\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests (experimental group vs. usual care\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.65; experimental group vs. attention control\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.94), nor at 2, 4, and 6\u00a0months post\u2010randomization using a mixed effect linear regression model and adjusting for baseline characteristics and random effect of time (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.55\u20130.99). In exploratory analyses, stage III experimental group participants seemed to present higher post\u2010traumatic growth on the PTGI 2\u00a0months post\u2010randomization than patients in the AC (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02), but this was not significant when applying a Bonferroni correction for multiple comparisons.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical implications<\/jats:title>\n                    <jats:p>In this three\u2010arm randomized controlled trial, the MMi did not produce improvements on the primary or secondary outcomes compared with AC or UC. There may be some indications of a signal for benefit for patients with stage III cancer, which warrant follow\u2010up but cannot be considered definitive. Future work should prioritize targeting, dose, timing, and contextual moderators to clarify when, and for whom, meaning\u2010focused approaches are most effective.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pon.70421","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T03:45:17Z","timestamp":1773978317000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Randomized Controlled Trial of the Meaning\u2010Making Intervention (MMi) in Patients Newly Diagnosed With Advanced Cancer: Full Trial"],"prefix":"10.1002","volume":"35","author":[{"given":"Melissa","family":"Henry","sequence":"first","affiliation":[{"name":"McGill University  Montreal Quebec Canada"},{"name":"Jewish General Hospital  Montreal Quebec Canada"},{"name":"Lady Davis Institute for Medical Research  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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