{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:25:46Z","timestamp":1790742346776,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["202340048"],"award-info":[{"award-number":["202340048"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Clinical evidence guiding the fertility decisions of reproductive\u2010age patients with breast cancer remains limited. No study has reported the impact of fertility preservation interventions on the decision\u2010making process of patients with breast cancer. Fertility preservation interventions reduce fertility decision\u2010making conflicts and address psychological issues in patients with breast cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We evaluated the effectiveness of fertility preservation interventions, including educational materials, decision aids, and counseling models in facilitating informed fertility\u2010related decision\u2010making among reproductive\u2010age patients newly diagnosed with breast cancer. Additionally, we examined the influence of these interventions on patients' psychological state.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We searched PubMed, Embase,\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      , and the Cochrane Library from inception to February 20, 2025. Randomized controlled trials and non\u2010randomized controlled trials that reported the effects of fertility preservation interventions on fertility decision making among patients with breast cancer were included. Two authors independently screened the studies, assessed their quality, and extracted the data. Bias risk was assessed using the Cochrane risk\u2010of\u2010bias tool for randomized trials.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The interventions were categorized as decision aids, educational interventions, and psychological interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Fertility preservation interventions significantly enhanced the fertility knowledge of patients with breast cancer, particularly interventions such as decision aids. However, no single intervention demonstrated distinct superiority specifically in terms of mitigating decisional conflict and alleviating patients' psychological distress. Fertility preservation interventions, when combined with specialist consultation, enhanced fertility\u2010related knowledge and had a positive impact on fertility decision making. High\u2010quality research is recommended to enrich fertility preservation interventions and encourage multidisciplinary teamwork to enhance fertility decision\u2010making.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>The protocol was registered on PROSPERO (Registration number: CRD420251007625)<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pon.70452","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T03:27:23Z","timestamp":1775618843000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Impact of Fertility Preservation Interventions on Fertility Decision Making in Patients With Breast Cancer: A Systematic 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4499-5798","authenticated-orcid":false,"given":"Liangjing","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Nursing Shanghai Key Laboratory of Maternal Fetal Medicine Shanghai Institute of Maternal\u2010Fetal Medicine and Gynecologic Oncology Shanghai First Maternity and Infant Hospital School of Medicine Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3296-5339","authenticated-orcid":false,"given":"Xianliang","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Nursing and Health Studies Hong Kong Metropolitan University  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjin","family":"Cen","sequence":"additional","affiliation":[{"name":"Department of Nursing Renji Hospital Shanghai Jiao Tong University School of 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