{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:43:24Z","timestamp":1791499404345,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:00:00Z","timestamp":1776470400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chemotherapy\u2010induced peripheral neuropathy (CIPN) is a debilitating toxicity. While social support is protective, its precise mechanisms remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To test whether social support influences CIPN symptoms through physical activity and psychological distress, and if mediation is full or partial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective cohort of 240 breast cancer patients was enrolled and assessed longitudinally at three time points: baseline, 6\u00a0weeks, and 12\u00a0weeks. Using structural equation modeling, a partial mediation model (with a direct social support\u2010CIPN path) was compared to a full mediation model (path constrained) via a likelihood ratio test. Indirect effects were tested with bootstrapping.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Model comparison supported the full mediation (\u0394\u03c7\n                      <jats:sup>2<\/jats:sup>\n                      (1)\u00a0=\u00a00.22,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.639). Higher baseline social support was associated with greater week\u20106 physical activity (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a00.668) and lower week\u20106 psychological distress (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a0\u22120.602). These mediators subsequently predicted week\u201012 CIPN symptoms (physical activity:\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a0\u22120.403; psychological distress:\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a00.361). Significant indirect effects were found for both the physical activity pathway (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a0\u22120.271) and the psychological distress pathway (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a0\u22120.219). The model explained 47.6% of the variance in CIPN symptoms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The protective effect of social support on CIPN symptoms operates predominantly by promoting physical activity and buffering psychological distress. These findings support integrated, mechanism\u2010informed interventions leveraging social resources to mitigate a debilitating burden of treatment\u2010related symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pon.70470","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T16:55:03Z","timestamp":1776531303000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Social Support and Chemotherapy\u2010Induced Peripheral Neuropathy in Breast Cancer: A Full Mediation Dual\u2010Pathway Model Through Physical Activity and Psychological Distress"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0720-0750","authenticated-orcid":false,"given":"Huijie","family":"Wei","sequence":"first","affiliation":[{"name":"First Affiliated Hospital of Jinzhou Medical University  Jinzhou China"},{"name":"School of Nursing, Jinzhou Medical University  Jinzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wubin","family":"He","sequence":"additional","affiliation":[{"name":"Key Laboratory of Surgery of Liaoning Province of the First Affiliated Hospital of Jinzhou Medical University  Jinzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/NCC.0000000000000764"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.NAJ.0000742060.56042.e7"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2024.2367"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2025.15254"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2025.08.002"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010023\u201007734\u20102"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/abm\/kaaa101"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14051224"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.1005083"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.21037\/apm\u201024\u2010154"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549\u2010024\u201007342\u20106"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16142571"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jncc.2022.06.002"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12905\u2010021\u201001307\u20103"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/nur.20008"},{"issue":"3","key":"e_1_2_11_17_1","first-page":"265","article-title":"Reliability and Validity of the Chinese Version of the International Physical Activity Questionnaire","volume":"25","author":"Li H. 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