{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T13:10:35Z","timestamp":1779887435695,"version":"3.53.1"},"reference-count":55,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T00:00:00Z","timestamp":1777766400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007046","name":"Wuhan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Breast cancer patients often experience significant psychological distress. This study examined distress trajectories from diagnosis to 6\u00a0months post\u2010treatment and explored differences across demographic, medical, and psychosocial subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective cohort study, 528 patients with breast cancer were recruited between 1 December 2023 and 31 December 2024. Assessments were conducted at baseline (at diagnosis, T0), after the first treatment (T1), mid\u2010treatment (T2), at treatment completion (T3), and at three (T4) and six months (T5) post\u2010treatment. Growth mixture modeling (GMM) was used to identify distinct trajectories of psychological distress. Multinomial logistic regression analysis was performed to examine associations between patient\u2010related factors and trajectory membership.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Three psychological distress trajectories were identified: a high\u2010distress remission group (17.05%), a moderate\u2010stable distress group (11.93%), and a low\u2010fluctuating distress group (71.02%). Multivariable analyses showed that higher educational attainment, breast\u2010conserving surgery, early disease stage, partial self\u2010management ability, and strong social support were associated with membership in the moderate\u2010stable or low\u2010fluctuating groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Employment, health insurance coverage, avoidant medical coping style, and higher baseline anxiety and depression scores were concurrently associated with membership in the high\u2010distress remission group (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although psychological distress generally decreased over time, 71.02% of patients followed a low\u2010fluctuating trajectory, 11.93% maintained moderate distress with potential risk of persistence, and 17.05% showed high initial distress that remitted substantially within 6\u00a0months. Continuous monitoring and early psychosocial support are recommended, particularly for patients with moderate\u2010 or high\u2010risk trajectories.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pon.70474","type":"journal-article","created":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T08:08:53Z","timestamp":1777795733000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Psychological Distress Trajectories and Associated Factors in Patients With Breast Cancer: A Cohort Study"],"prefix":"10.1002","volume":"35","author":[{"given":"Meidi","family":"Xiong","sequence":"first","affiliation":[{"name":"Zhongnan Hospital of Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Zhongnan Hospital of Wuhan University  Wuhan 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