{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T20:28:13Z","timestamp":1783110493792,"version":"3.54.6"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["72504092"],"award-info":[{"award-number":["72504092"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Middle\u2010aged and older cancer survivors experience frailty related to both age and cancer. While studies have explored the associations between risk factors and frailty in this population, there is still a gap in understanding the long\u2010term associations and mechanisms linking adverse childhood experiences (ACEs) to frailty in later life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study examines the long\u2010term association between a social connectedness\u2010oriented dimension of ACEs\u2014adverse childhood friendships\u2014and frailty in later life among cancer survivors. Additionally, this study seeks to elucidate the mediating mechanisms by investigating the roles of social isolation in later life, as well as its offline (physical inactivity) and online (digital exclusion) components.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study analyzed a sample of 419 middle\u2010aged and older cancer survivors, with a mean age of 63.41\u00a0years (SD\u00a0=\u00a09.64), drawn from the 2014 and 2020 waves of the China Health and Retirement Longitudinal Study. Structural equation modeling was employed to test the proposed model. Additional multigroup analyses were conducted to examine whether the proposed associations differed by gender.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Adverse childhood friendships exhibit a significant long\u2010term association with increased frailty in later life among cancer survivors. Furthermore, overall social isolation, along with its offline (physical inactivity) and online (digital exclusion) components, serves as mediating factors in this long\u2010term relationship. Multigroup analyses revealed no significant gender differences in the structural pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The observed long\u2010term association underscores the importance of integrating a life\u2010course perspective on ACEs into intervention and care strategies for middle\u2010aged and older cancer survivors. Besides, addressing social isolation\u2014both offline and online\u2014may be considered as a potential component of comprehensive care programs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pon.70524","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T13:56:12Z","timestamp":1782395772000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Long Arm of Adverse Childhood Friendships Among Middle\u2010Aged and Older Cancer Survivors: Associations With Social Isolation and Frailty in Later Life"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6865-9966","authenticated-orcid":false,"given":"Jiaming","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Social Security School of Public Administration Southwestern University of Finance and Economics  Chengdu Sichuan 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