{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:06:14Z","timestamp":1785323174736,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010237","name":"National Society of Genetic Counselors","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010237","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>There is a paucity of evidence\u2010based psychosocial resources for individuals and families impacted by Li\u2010Fraumeni Syndrome (LFS). This mixed\u2010methods study aimed to (1) establish interest in and need for a dedicated LFS psychotherapy group, (2) design and implement a psychotherapy group, and (3) evaluate participant experiences and gather feedback for future group interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eligible participants were English\u2010speaking, \u2265\u00a018\u00a0years, and an individual with LFS or a caregiver\/family member. An anonymous needs assessment survey determined preferences, formatting and content for a psychotherapy group. Sixteen virtual psychotherapy groups were conducted between September 2020 and April 2024. Semi\u2010structured post\u2010group interviews assessed group experience and perceived utility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Majority (77.4%) of survey participants (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a031) reported difficulty finding support. Participants aged 18\u201339 were significantly more interested than those aged \u2265\u00a040 in discussing themes such as family planning (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), communication with children (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.038), psychosocial support needs (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.004), couple dynamics (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), and body image and identity (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.014). A total of 34 individuals joined at least one group, with an average of 6.2 participants\/group (range 0\u201312). Thematic analysis of interviews (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a014) demonstrated that participants found the group constructive and largely endorsed the format and facilitation. Six interview themes were extracted: Community, Support and Connection, Structure and Delivery, Group Topics and Themes, Education, Group Composition, and Fostering Hope.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A dedicated LFS psychotherapy group, led by facilitators with LFS and mental health expertise, is an acceptable psychosocial resource offering connection for people with this rare diagnosis. Data provides a format for implementing this intervention at other centers, with potential for future research and improving care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pon.70541","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T13:47:18Z","timestamp":1783432038000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design and Implementation of a Psychotherapy Group Program for Individuals and Families Impacted by Li\u2010Fraumeni Syndrome: A Pilot Study"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7302-1564","authenticated-orcid":false,"given":"Kelsey","family":"Breen","sequence":"first","affiliation":[{"name":"Department of Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0899-9560","authenticated-orcid":false,"given":"Marie","family":"Barnett","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Gilliland","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Tutino","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1287-4015","authenticated-orcid":false,"given":"Giulia","family":"Ongaro","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith","family":"MacGregor","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry and Behavioral Sciences Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199205143262002"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1167"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.23673"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xhgg.2023.100242"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(03)12856\u20105"},{"issue":"2","key":"e_1_2_10_7_1","first-page":"83","article-title":"Germ\u2010Line p53 Mutations Predispose to a Wide Spectrum of Early\u2010Onset Cancers","volume":"10","author":"Nichols K. 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