{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:06:27Z","timestamp":1785323187977,"version":"3.55.0"},"reference-count":61,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["T32HD068223"],"award-info":[{"award-number":["T32HD068223"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pain is a common and distressing symptom for pediatric patients with acute lymphoblastic leukemia (ALL), arising from the disease itself, its treatment, and associated medical procedures. The early phase of treatment is particularly challenging, as children experience multiple, rapidly evolving sources of pain. Despite its prevalence, pain during this period remains poorly characterized. This study qualitatively examined pain experiences among children with ALL during induction and early consolidation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty caregivers of children with ALL (ages 2\u201317) and eight patients (ages 8\u201317) participated in two semi\u2010structured interviews capturing pain experiences across early treatment. Interviews were audio\u2010recorded, transcribed, and analyzed using thematic analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eight themes described key dimensions of the pain experience: Sources of Pain, Pain Characteristics, Pain\u2010Related Symptoms, Factors Influencing Pain, Pain Impact, Pain Expression, Pain Management Tools, and Barriers to Pain Management. These themes reflected the evolving, multidimensional nature of pain during early treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Children with ALL experience substantial and multifaceted pain early in their cancer trajectory. Findings underscore the need for early, developmentally informed, and family\u2010centered approaches to pain assessment and management that address the complex and evolving nature of pain during initial treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pon.70550","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T07:54:47Z","timestamp":1784015687000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pain Experiences During Early Treatment for Pediatric Acute Lymphoblastic Leukemia: A Qualitative Study"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4433-5924","authenticated-orcid":false,"given":"Kimberly L.","family":"Klages","sequence":"first","affiliation":[{"name":"Division of Behavioral Medicine and Clinical Psychology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecelia I.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Division of Behavioral Medicine and Clinical Psychology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia K.","family":"Herriott","sequence":"additional","affiliation":[{"name":"Division of Behavioral Medicine and Clinical Psychology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin E.","family":"Norris","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Cincinnati College of Medicine  Cincinnati Ohio USA"},{"name":"Division of Oncology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan E.","family":"McGrady","sequence":"additional","affiliation":[{"name":"Division of Behavioral Medicine and Clinical Psychology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susmita","family":"Kashikar\u2010Zuck","sequence":"additional","affiliation":[{"name":"Division of Behavioral Medicine and Clinical Psychology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahna L. H.","family":"Pai","sequence":"additional","affiliation":[{"name":"Center for Biobehavioral Health Abigail Wexner Research Institute Nationwide Children's Hospital  Columbus Ohio USA"},{"name":"Department of Pediatrics The Ohio State University School of Medicine  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u20103476(05)80535\u20109"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29708"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006199\u2010200401000\u201000001"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20432"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29876"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010014\u20102349\u20102"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26489"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e31827080de"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969\u2010019\u20100376\u20108"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001261"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1043454209339733"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph14121468"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440\u20101746.2011.06908.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03262792"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2009.172528"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428191003754608"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477\u20107525\u20106\u2010103"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jns.12114"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26471"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.4274\/tjh.galenos.2018.2018.0150"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2017.12.019"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra1400972"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2011.08.006"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.47.8867"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2014.06.006"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002485"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136\u2010016\u20101462\u20108"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs\u20102016\u20100001"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.23039"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24096"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477\u20107525\u20106\u201096"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25433"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.70063"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/med:psych\/9780199763979.001.0001"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpaic.2019.03.003"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20104642(20)30277\u20107"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/2049463714550507"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000000670"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2015.08.007"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jss099"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/09638288.2016.1207107"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0089454"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186x.2014.995774"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098\u2010240x(200008)23:4<334::aid\u2010nur9>3.0.co;2\u2010g"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/nur.20362"},{"key":"e_1_2_10_47_1","volume-title":"Successful Qualitative Research: A Practical Guide for Beginners","author":"Clarke V.","year":"2013"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.4135\/9781036232078.n9"},{"key":"e_1_2_10_49_1","volume-title":"Qualitative Inquiry and Research Design: Choosing Among Five Approaches","author":"Creswell J. W.","year":"2018"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1177\/1609406917733847"},{"key":"e_1_2_10_51_1","volume-title":"Qualitative Data Analysis: A Methods Sourcebook","author":"Miles M.","year":"2020"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1177\/1609406919899220"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1177\/1468794112468475"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/nursrep15050163"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedhc.2025.01.009"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119701170.ch9"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1542\/hpeds.2013\u20100031"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526\u20104637.2011.01289.x"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-6413-9_6"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2004.05.001"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2012.02.020"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912\u2010020\u20100899\u20107"}],"container-title":["Psycho-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pon.70550","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pon.70550","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pon.70550","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T10:48:04Z","timestamp":1785322084000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pon.70550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":61,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/pon.70550"],"URL":"https:\/\/doi.org\/10.1002\/pon.70550","archive":["Portico"],"relation":{},"ISSN":["1057-9249","1099-1611"],"issn-type":[{"value":"1057-9249","type":"print"},{"value":"1099-1611","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-04-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70550"}}