{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:06:19Z","timestamp":1785323179669,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["91101002"],"award-info":[{"award-number":["91101002"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Depression is a heterogeneous construct comprising distinct symptom domains, including motivational anhedonia, consummatory anhedonia, and negative affect, commonly experienced by colorectal cancer (CRC) survivors. Inflammation has been implicated in depression, its association with specific depressive symptom domains in CRC survivors remains insufficiently characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      CRC patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0497) completed questionnaires assessing depressive symptoms 12\u2010 and 24\u2010months post\u2010diagnosis: motivational anhedonia (Multidimensional Fatigue Inventory), consummatory anhedonia (Hospital Anxiety and Depression Scale\u2013depression), and negative affect (EORTC QLQ\u2010C30, emotional functioning). Associations between 11 inflammatory markers (CRP, IL\u20101\u03b1, IL\u20101\u03b2, IL\u20106, IL\u20108, IL\u201010, IL\u201017A, IL\u201022, IFN\u2010\u03b3, sTNFRI, and sTNFRII) at 12\u2010months and depressive symptoms at 12\u2010 and 24\u2010months were examined using linear mixed models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      IL\u20101\u03b2 (Est\u00a0=\u00a00.089,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.003) and IFN\u2010\u03b3 (Est\u00a0=\u00a00.067,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001) were associated with more consummatory anhedonia symptoms across time, and a small sTNFRI\u00a0\u00d7\u00a0time interaction was found (Est\u00a0=\u00a00.000,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.007). Negative affect was associated with IL\u20101\u03b2 (Est\u00a0=\u00a0\u22120.496,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), IFN\u2010\u03b3 (Est\u00a0=\u00a0\u22120.354,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), and sTNFRI (Est\u00a0=\u00a0\u22120.003,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). A significant IL\u20101\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u00a0\u00d7\u00a0time interaction was observed (Est\u00a0=\u00a00.250,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.038) for motivational anhedonia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Most consistently IL\u20101\u03b2, IFN\u2010\u03b3, and sTNFRI was associated with greater consummatory anhedonia and more negative affect in CRC survivors. In addition, inflammatory correlates (IL\u20101\u03b1 and sTNFRI) of motivational anhedonia and consummatory anhedonia changed over time. These findings suggest that selected inflammatory pathways may contribute to specific depressive symptom domains during colorectal cancer survivorship. Given the exploratory nature of the analyses, replication in independent cohorts is required before clinical implications can be drawn.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pon.70555","type":"journal-article","created":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T10:32:44Z","timestamp":1784370764000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal Associations Between Inflammatory Markers at 12\u2010Months and Three Core Symptoms of Depression at 12\u2010 and 24\u2010Months After Colorectal Cancer Diagnosis: Results From the Population\u2010Based PROFILES Registry"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2240-6349","authenticated-orcid":false,"given":"Chris","family":"Hinnen","sequence":"first","affiliation":[{"name":"Department of Medical Psychology Spaarne Gasthuis  Haarlem the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0818-2913","authenticated-orcid":false,"given":"Floortje","family":"Mols","sequence":"additional","affiliation":[{"name":"CoRPS\u2014Center of Research on Psychological Disorders and Somatic Diseases Department of Medical and Clinical Psychology Tilburg University  Tilburg the Netherlands"},{"name":"Department of Research &amp; Development Netherlands Comprehensive Cancer Organisation (IKNL)  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4476-2747","authenticated-orcid":false,"given":"Dounya","family":"Schoormans","sequence":"additional","affiliation":[{"name":"CoRPS\u2014Center of Research on Psychological Disorders and Somatic Diseases Department of Medical and Clinical Psychology Tilburg University  Tilburg the Netherlands"},{"name":"Department of Research &amp; Development Netherlands Comprehensive Cancer Organisation (IKNL)  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,18]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2016.11.017"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjc.12435"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/08870446.2022.2155670"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2015.00309"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2017.1307737"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.3954"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.3409"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.34193"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2015.5"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2021_294"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010020\u201000920\u20104"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2025.0206"},{"key":"e_1_2_14_15_1","article-title":"Effects of Cancer Treatment on Inflammation in Colorectal Cancer Patients: A Longitudinal Study","author":"Bruijnzeels A. 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