{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:09:01Z","timestamp":1791356941920,"version":"4.3.1"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102025\u201023963393"],"award-info":[{"award-number":["RS\u20102025\u201023963393"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102023\u201000209077"],"award-info":[{"award-number":["RS\u20102023\u201000209077"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Depression and anxiety are hypothesized to increase the risk for the development of chronic disease(s), including cancer. Several published observational studies and meta\u2010analyses have investigated the link between depression and anxiety in cancer but have reported conflicting results. To clarify this relationship, a meta\u2010analysis of observational studies reporting an association between depression, anxiety, and cancer incidence was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective and retrospective cohort studies investigating the relationship between depression, anxiety, and cancer incidence were included. A literature search of the PubMed was performed, with the final search conducted in March 2026. Egger's test and funnel plots were used to evaluate publication bias. Meta\u2010analysis was performed using a random\u2010effects model because high heterogeneity among the studies was expected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the analysis including both retrospective and prospective studies, patients with depression or anxiety exhibited an elevated risk for lung, hepatobiliary\u2010pancreatic (HBP), hematological, and kidney, ureter, and bladder (KUB) cancers. In the analysis including only prospective studies, patients with depression or anxiety exhibited an elevated risk for female reproductive organ and lung cancer. Finally, in the analysis including only retrospective studies, patients with depression or anxiety exhibited an elevated risk for lung, HBP, hematological, KUB, and oral cancers, and a notably lower risk for female reproductive organ cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Results of this study revealed that depression and anxiety were associated with an elevated risk for specific cancers. A future meta\u2010analysis including only prospective cohort studies with the same measures of depression or anxiety may further clarify this relationship.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pon.70559","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T10:38:51Z","timestamp":1786617531000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association Between Psychological Distress and Site\u2010Specific Cancer Incidence: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3667-6814","authenticated-orcid":false,"given":"Shin Tae","family":"Kim","sequence":"first","affiliation":[{"name":"Institute of Behavioral Science in Medicine Yonsei University College of Medicine  Seoul Republic of Korea"},{"name":"Department of Psychiatry Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0119-0443","authenticated-orcid":false,"given":"Chun Il","family":"Park","sequence":"additional","affiliation":[{"name":"Institute of Behavioral Science in Medicine Yonsei University College of Medicine  Seoul Republic of Korea"},{"name":"Department of Psychiatry Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Yeob","family":"Kim","sequence":"additional","affiliation":[{"name":"Samsung Advanced Institute for Health Sciences and Technology Sungkyunkwan University Samsung Medical Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5438-8210","authenticated-orcid":false,"given":"Se Joo","family":"Kim","sequence":"additional","affiliation":[{"name":"Institute of Behavioral Science in Medicine Yonsei University College of Medicine  Seoul Republic of Korea"},{"name":"Department of Psychiatry Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2818-7183","authenticated-orcid":false,"given":"Jee In","family":"Kang","sequence":"additional","affiliation":[{"name":"Institute of Behavioral Science in Medicine Yonsei University College of Medicine  Seoul Republic of Korea"},{"name":"Department of Psychiatry Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2326-1820","authenticated-orcid":false,"given":"Jae Il","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Yonsei University College of Medicine  Seoul Republic of Korea"},{"name":"Severance Underwood Meta\u2010Research Center Institute of Convergence Science Yonsei University  Seoul Republic of Korea"},{"name":"The Center for Medical Education Training and Professional Development Yonsei Donggok Medical Education Institute  Seoul Republic of Korea"},{"name":"Section of Digestive Diseases Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(13)61611\u20106"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1820"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2007.12.008"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncponc1134"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2017.04.026"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010019\u20100595\u2010x"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745\u20100179\u20103\u201029"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.4084"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.34853"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.7314\/apjcp.2015.16.8.3233"},{"key":"e_1_2_14_12_1","unstructured":"G. A.Wells B.Shea D.O\u2019Connell et\u00a0al. The Newcastle\u2010Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in meta\u2010analyses (2000)."},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0033291720004390"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604313"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24086"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2006.08.012"}],"container-title":["Psycho-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pon.70559","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pon.70559","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pon.70559","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:38:06Z","timestamp":1789569486000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pon.70559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/pon.70559"],"URL":"https:\/\/doi.org\/10.1002\/pon.70559","archive":["Portico"],"relation":{},"ISSN":["1057-9249","1099-1611"],"issn-type":[{"value":"1057-9249","type":"print"},{"value":"1099-1611","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2026-05-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70559"}}