{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:56:38Z","timestamp":1790618198663,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Cancer\u2010related distress extends beyond anxiety and depression to existential suffering, including loss of meaning, helplessness, uncertainty, and relational strain. Compassion\u2010based interventions in psycho\u2010oncology are promising, but existential outcomes such as demoralization and spiritual well\u2010being have rarely been examined.\n                      <jats:italic>Compassion With You<\/jats:italic>\n                      (COMwithU) is a brief, five\u2010session compassion\u2010based intervention that centers on cultivating self\u2010compassion, supported by the therapist's compassionate presence and by practices of extending compassion toward others.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single\u2010arm feasibility study evaluated COMwithU in adult patients with cancer using a pre\u2010post\u20101\u2010month follow\u2010up design. The intervention comprised five individual 60\u2010min sessions delivered in person or via videoconferencing. Primary outcomes were feasibility and acceptability. Secondary outcomes included anxiety, depression, spiritual well\u2010being, demoralization, self\u2010compassion, and intolerance of uncertainty. Linear mixed models examined changes across baseline, post\u2010intervention, and follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 44 participants who started the intervention, 37 attended at least 3 of 5 sessions, yielding a completion rate of 84.1%. Among 34 full completers, 31 (91.2%) completed the post\u2010intervention assessment, and 30 (88.2%) completed the follow\u2010up. Helpfulness was rated highly (mean 4.63\/5). Anxiety, depression, spiritual well\u2010being, demoralization, and self\u2010compassion improved significantly, whereas intolerance of uncertainty did not change significantly. Among participants above the demoralization cutoff at baseline, 68.0% showed reliable improvement, and 56.0% achieved clinically significant change by follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>COMwithU demonstrated good feasibility, high acceptability, and promising preliminary effects in patients with cancer. The strongest effects were observed for demoralization and spiritual well\u2010being. Further randomized controlled trials should directly assess self\u2010compassion, relational compassion processes, and existential outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>This study was registered at the Clinical Research Information Service (CRIS), Republic of Korea (Registration number: KCT0010315)<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pon.70580","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T05:39:21Z","timestamp":1787895561000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Addressing Existential Distress Through Compassion: Feasibility and Preliminary Effects of\n                    <i>Compassion With You<\/i>\n                    (COMwithU), a Compassion\u2010Based Intervention for Patients With Cancer"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3405-8089","authenticated-orcid":false,"given":"Yeonkyu","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Psychiatry Seoul National University Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5457-7577","authenticated-orcid":false,"given":"Jang Sub","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Seoul National University Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2129-064X","authenticated-orcid":false,"given":"Hyejeong","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Seoul National University Hospital  Seoul Republic of Korea"},{"name":"Department of Human Systems Medicine Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9083-6001","authenticated-orcid":false,"given":"Soowan","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Seoul National University Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8889-9473","authenticated-orcid":false,"given":"Min Cheol","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Seoul National University College of Medicine  Seoul Republic of Korea"},{"name":"Department of Psychiatry Uijeongbu Eulji Medical Center  Gyeonggi\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4637-4350","authenticated-orcid":false,"given":"Jae Hyun","family":"Ryou","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Seoul National University Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4232-6257","authenticated-orcid":false,"given":"Da Eun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Social Welfare Seoul National University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4548-0653","authenticated-orcid":false,"given":"Yoosuk","family":"An","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Seoul National University Hospital  Seoul Republic of Korea"},{"name":"Department of Psychiatry Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8196-4247","authenticated-orcid":false,"given":"Bhumsuk","family":"Keam","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul 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