{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:05:09Z","timestamp":1789571109419,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Psychological distress is an important component of cancer survivorship, particularly among patients undergoing radical cystectomy (RC) for bladder cancer. However, the prognostic significance of postoperative psychiatric medication exposure following RC remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate the association between postoperative antidepressant and\/or anxiolytic exposure and survival outcomes following RC for bladder cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective propensity score\u2013matched cohort study used data from the TriNetX US Collaborative Network. Adult patients who underwent RC for bladder cancer (2005\u20132025) were identified. Postoperative psychiatric medication exposure was defined as new use of antidepressants (Anatomical Therapeutic Chemical: N06A) and\/or anxiolytics (ATC: N05B). The primary analysis evaluated combined antidepressant\/anxiolytic exposure, with separate antidepressant\u2010only and anxiolytic\u2010only subgroup analyses. Overall survival (OS) and all\u2010cause mortality were evaluated after 1:1 propensity score matching (PSM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The primary analysis identified 2461 exposed and 7257 unexposed patients, yielding 1521 matched pairs after PSM. Patients exposed to postoperative psychiatric medication were associated with significantly poorer OS than their matched controls (hazard ratio [HR]: 1.377, 95% confidence interval [CI]: 1.261\u20131.502; log\u2010rank\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Similar associations were observed in subgroup analyses. Antidepressant\u2010only exposure was associated with poorer OS (HR: 1.260, 95% CI: 1.161\u20131.367;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), and the anxiolytic\u2010only subgroup demonstrated the strongest association with poorer survival (HR: 1.457, 95% CI: 1.324\u20131.604;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Psychiatric medication use may represent a clinically observable marker of psychological burden and survivorship vulnerability following RC. Early recognition of postoperative psychological vulnerability may facilitate timely psycho\u2010oncological support and multidisciplinary survivorship care following RC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pon.70581","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T11:54:11Z","timestamp":1786967651000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Postoperative Antidepressant and Anxiolytic Exposure With Overall Survival Following Radical Cystectomy for Bladder Cancer"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6635-3699","authenticated-orcid":false,"given":"Cheng\u2010Shuo","family":"Huang","sequence":"first","affiliation":[{"name":"College of Biomedical Sciences Graduate Institute of Life Sciences National Defense Medical University  Taipei Taiwan"},{"name":"College of Medicine Graduate Institute of Pathology and Parasitology National Defense Medical University  Taipei Taiwan"},{"name":"Department of Pathology Tri\u2010Service General Hospital National Defense Medical University  Taipei Taiwan"},{"name":"National Institute of Cancer Research National Health Research Institutes  Miaoli Taiwan"},{"name":"Department of Integrative Biology and Pharmacology McGovern Medical School the University of Texas Health Science Center at Houston  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai\u2010Hsiang","family":"Tung","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Tri\u2010Service General Hospital Beitou Branch  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0059-3253","authenticated-orcid":false,"given":"Ying\u2010Si","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Biomedical Sciences Graduate Institute of Life Sciences National Defense Medical University  Taipei Taiwan"},{"name":"College of Medicine Graduate Institute of Pathology and Parasitology National Defense Medical University  Taipei Taiwan"},{"name":"Department of Pathology Tri\u2010Service General Hospital National Defense Medical University  Taipei Taiwan"},{"name":"Department of Integrative Biology and Pharmacology McGovern Medical School the University of Texas Health Science Center at Houston  Houston Texas USA"},{"name":"Department of Surgery Division of Urology Tri\u2010Service General Hospital National Defense Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010Ping","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Biomedical Sciences Graduate Institute of Life Sciences National Defense Medical University  Taipei Taiwan"},{"name":"College of Medicine Graduate Institute of Pathology and Parasitology National Defense Medical University  Taipei Taiwan"},{"name":"Department of Pathology Tri\u2010Service General Hospital National Defense Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dah\u2010Shyong","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Biomedical Sciences Graduate Institute of Life Sciences National Defense Medical University  Taipei Taiwan"},{"name":"Department of Surgery Division of Urology Tri\u2010Service General Hospital National Defense Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9093-1009","authenticated-orcid":false,"given":"Ming\u2010Hsin","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Biomedical Sciences Graduate Institute of Life Sciences National Defense Medical University  Taipei Taiwan"},{"name":"Department of Surgery Division of Urology Tri\u2010Service General Hospital National Defense Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5543-7101","authenticated-orcid":false,"given":"Yong\u2010Eng","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Shin Kong Wu Ho\u2010Su Memorial Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6933-041X","authenticated-orcid":false,"given":"Jar\u2010Yi","family":"Ho","sequence":"additional","affiliation":[{"name":"College of Biomedical Sciences Graduate Institute of Life Sciences National Defense Medical University  Taipei Taiwan"},{"name":"College of Medicine Graduate Institute of Pathology and Parasitology National Defense Medical University  Taipei Taiwan"},{"name":"Department of Pathology Tri\u2010Service General Hospital National Defense Medical University  Taipei 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