{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:06:05Z","timestamp":1789571165349,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cancer\u2010related cognitive impairment (CRCI) is a prevalent yet underrecognized complication among colon cancer survivors that adversely affects quality of life and psychological well\u2010being. Emerging evidence suggests that neurotrophic dysregulation and systemic inflammation may contribute to chemotherapy\u2010related neurotoxicity; however, longitudinal biomarker\u2010based data remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective cohort study, 127 patients with resected colon cancer were evaluated at baseline and at the 6\u2010month follow\u2010up. Of these, 83 received adjuvant chemotherapy and 44 underwent postoperative surveillance alone. Cognitive performance (MoCA), depressive symptoms (HADS\u2010D), and peripheral neuropathy (CIPN20) were assessed alongside serum brain\u2010derived neurotrophic factor (BDNF) levels and systemic inflammatory markers, including neutrophil\u2010to\u2010lymphocyte ratio (NLR) and C\u2010reactive protein\u2010to\u2010albumin ratio (CAR). Linear mixed model and logistic regression analyses were performed to identify factors associated with cognitive decline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Adjuvant chemotherapy was associated with significant reductions in MoCA scores and serum BDNF levels (both\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), particularly among patients receiving the oxaliplatin\u2010based XELOX regimen. Greater longitudinal reductions in BDNF (\u0394BDNF) were independently associated with higher odds of CRCI (OR\u00a0=\u00a00.749 per 10\u00a0ng\/mL increase in \u0394BDNF, 95% CI: 0.658\u20130.854,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). The model including \u0394BDNF showed higher apparent discrimination than the corresponding model without \u0394BDNF (AUC\u00a0=\u00a00.929 vs. 0.812).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Longitudinal reductions in serum BDNF were independently associated with CRCI among patients receiving adjuvant chemotherapy. These findings support a potential role for neurotrophic dysregulation in chemotherapy\u2010related cognitive decline and highlight the need for further validation studies evaluating BDNF as a candidate biomarker for CRCI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pon.70590","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T15:34:51Z","timestamp":1787672091000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neurotrophic\u2013Inflammatory Imbalance and Cognitive Decline After Adjuvant Chemotherapy in Colon Cancer: A Prospective Cohort Study"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8960-2208","authenticated-orcid":false,"given":"Zeynep G\u00fcls\u00fcm","family":"G\u00fc\u00e7","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Atat\u00fcrk Training and Research Hospital \u0130zmir Katip \u00c7elebi University  \u0130zmir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9174-8935","authenticated-orcid":false,"given":"Leyla","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Atat\u00fcrk Training and Research Hospital \u0130zmir Katip \u00c7elebi University  \u0130zmir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4032-9209","authenticated-orcid":false,"given":"H\u00fcseyin","family":"D\u00f6ngelli","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Buca Seyfi Demirsoy Training and Research Hospital  \u0130zmir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9590-7306","authenticated-orcid":false,"given":"\u0130brahim","family":"Bilen","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Sakarya Training and Research Hospital  Sakarya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3055-0455","authenticated-orcid":false,"given":"Mert","family":"Uge","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Karab\u00fck Public Health Laboratory  Karab\u00fck T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2702-0170","authenticated-orcid":false,"given":"Mehmet Eren","family":"Kalender","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Atat\u00fcrk Training and Research Hospital \u0130zmir Katip \u00c7elebi University  \u0130zmir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0182-4012","authenticated-orcid":false,"given":"Ahmet","family":"Alacac\u0131o\u011flu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Atat\u00fcrk Training and Research Hospital \u0130zmir Katip \u00c7elebi University  \u0130zmir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8502-4348","authenticated-orcid":false,"given":"Mustafa Oktay","family":"Tarhan","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Institute of Oncology Dokuz Eyl\u00fcl University  \u0130zmir 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