{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T17:31:27Z","timestamp":1791739887759,"version":"4.3.4"},"reference-count":64,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2025A1515010640 (K0213689)"],"award-info":[{"award-number":["2025A1515010640 (K0213689)"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cancer\u2010related fatigue (CRF) is a prevalent and disabling symptom across the cancer continuum and is increasingly conceptualized as a biobehavioral symptom with inflammatory underpinnings. However, evidence linking specific circulating inflammatory biomarkers to CRF remains fragmented and inconsistent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To compare biomarker\u2010CRF associations across cross\u2010sectional and prospective observational studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, Web of Science, Cochrane Library, Embase, Scopus, and PsycINFO were searched from inception to 17 November 2025. Random\u2010effects meta\u2010analyses were stratified by study design and effect\u2010size metric; non\u2010comparable estimates were synthesized narratively. Certainty was assessed using GRADE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty\u2010two studies (11,629 participants) were included. Cross\u2010sectional CRF was positively associated with C\u2010reactive protein (CRP;\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.30, 95% CI 0.21\u20130.38). Positive associations were also observed for interleukin\u20106 (IL\u20106;\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.17, 95% CI 0.06\u20130.29) and tumor necrosis factor (TNF;\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.13, 95% CI 0.01\u20130.24). Interleukin\u20101 receptor antagonist was likewise associated with CRF (IL\u20101ra;\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.23, 95% CI 0.09\u20130.36). Prospectively, CRP was associated with subsequent CRF in odds ratio (OR\u00a0=\u00a01.20, 95% CI 1.05\u20131.37) and standardized regression syntheses (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a00.26, 95% CI 0.09\u20130.43). Evidence for IL\u20106, TNF, IL\u20101\u03b2, and IL\u20108 was less stable or inconclusive. Certainty was high for four evidence bodies, moderate for four, low for one, and very low for one.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Current evidence supports systemic inflammation as a clinically relevant biological correlate of CRF, with CRP\/hsCRP showing a comparatively more replicable signal across study designs. However, observational evidence does not establish causality or clinical utility. Standardized longitudinal and intervention studies are needed to evaluate temporal relationships, predictive performance, and clinical applicability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pon.70598","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T05:33:51Z","timestamp":1789104831000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Inflammatory Correlates and Prospective Associations of Cancer\u2010Related Fatigue: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7280-0803","authenticated-orcid":false,"given":"Lina","family":"Wu","sequence":"first","affiliation":[{"name":"School of Nursing Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyu","family":"Xiong","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohui","family":"Zhang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouzhen","family":"Cheng","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.02.016"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2020.103707"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010024\u201008615\u2010y"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416\u2010025\u201003116\u2010z"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010018\u20104318\u20107"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01827"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2023.11.020"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2013.07.177"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2011.04.003"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/10998004231215777"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.7293"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.5498\/wjp.v14.i7.1009"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0177620"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2021.02.008"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2023.104245"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2026.102236"},{"key":"e_1_2_12_19_1","volume-title":"Approximating Pearson Product\u2010Moment Correlations From Kendall's Tau and Spearman's Rho","author":"Rupinski M. T.","year":"1996"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.psych.52.1.59"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2019.12.023"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwae332"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20777"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764\u2010021\u201001115\u20106"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2020.09.011"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27613"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdh314"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269216311406991"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010024\u201008700\u20102"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2011.03.025"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2009.04.003"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.5986"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/1049909115603055"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi267"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010019\u201004717\u20100"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291717000150"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.4109"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgo.2019.04.009"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201008\u20102584"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.70038"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2012.04.003"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2024.07.728"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2025.102963"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40780\u2010023\u201000275\u20100"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/ecc.13055"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010025\u201009237\u20108"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2012.02.001"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010012\u20101625\u20102"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2012.07.022"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14319"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw252"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.NCC.0000305704.84164.54"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12123701"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2003.10.008"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8040543"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2015.10.016"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31537"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2012.06.011"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00754"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2022.10.003"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0165799"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2018.01.008"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058\u2010024\u201001898\u20103"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2025.103066"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2003.11.002"}],"container-title":["Psycho-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pon.70598","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pon.70598","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pon.70598","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:01:54Z","timestamp":1790614914000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pon.70598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":64,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/pon.70598"],"URL":"https:\/\/doi.org\/10.1002\/pon.70598","archive":["Portico"],"relation":{},"ISSN":["1057-9249","1099-1611"],"issn-type":[{"value":"1057-9249","type":"print"},{"value":"1099-1611","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-03-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70598"}}