{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:56:12Z","timestamp":1790618172198,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA177558"],"award-info":[{"award-number":["P30CA177558"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R34CA313778"],"award-info":[{"award-number":["R34CA313778"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Low rates of clinical trial participation, with notable disparities among rural populations, slow cancer treatment advances. Precision oncology protocols are designed to alleviate trial access barriers by consenting patients to sequencing with results matched to national databases of available trials. Precision oncology protocols represent a potential avenue for supporting patient informed trial decision\u2010making before they are offered a specific trial but little is known about clinical trial perceptions and intentions of patients who join such protocols.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We administered surveys to 116 patients with a cancer diagnosis enrolled in a precision oncology protocol at an Appalachia\u2010serving, academic cancer center. Analyses tested associations between clinical trial perceptions (e.g.,\u00a0beliefs, attitudes, knowledge), sociodemographic covariates, and trial intentions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Participants (mean age\u00a0=\u00a064.5; median education\u00a0=\u00a0high school; 97.4% white; 51.7% female; 60% Appalachian residence) held overall favorable clinical trial perceptions and overall positive intentions. Trial knowledge was significantly lower among participants with lower education, lower income, and those residing in Appalachian counties. Intentions were significantly associated with attitudes, beliefs around trying new treatments, and perceived family support for trial participation in both bivariate and multivariate regression analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study contributes to the literature by describing clinical trial perceptions among patients in a precision oncology prospective cohort from a cancer center that serves a predominately white, Appalachian population. Addressing patients' perceptions and concerns related to trials and involving family or support networks in the decision making process is likely to be a key element of supporting informed patient decision\u2010making for future trial opportunities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pon.70607","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:24:27Z","timestamp":1789561467000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Trial Perceptions Among Patients Enrolled in a Precision Oncology Protocol at an Appalachian\u2010Serving Cancer Center"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8501-1483","authenticated-orcid":false,"given":"Jerod L.","family":"Stapleton","sequence":"first","affiliation":[{"name":"Markey Cancer Center University of Kentucky  Lexington Kentucky USA"},{"name":"College of Public Health University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Leip","sequence":"additional","affiliation":[{"name":"College of Agriculture, Food, and Environment University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5311-144X","authenticated-orcid":false,"given":"Aurora","family":"Occa","sequence":"additional","affiliation":[{"name":"Markey Cancer Center University of Kentucky  Lexington Kentucky USA"},{"name":"College of Communication and Information University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Kolesar","sequence":"additional","affiliation":[{"name":"College of Pharmacy University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Belcher","sequence":"additional","affiliation":[{"name":"Markey Cancer Center University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin","family":"Deffendall","sequence":"additional","affiliation":[{"name":"College of Public Health University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9601-227X","authenticated-orcid":false,"given":"Taylor J.","family":"Webb","sequence":"additional","affiliation":[{"name":"Markey Cancer Center University of Kentucky  Lexington Kentucky USA"},{"name":"Centre College  Danville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Cavnar","sequence":"additional","affiliation":[{"name":"Markey Cancer Center University of Kentucky  Lexington Kentucky USA"},{"name":"College of Medicine University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djy221"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063\u2010017\u20102099\u20109"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/EDBK_243729"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pec.2020.10.007"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.4278\/ajhp.130514\u2010QUAL\u2010247"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/10810730.2019.1688895"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/17407745231204813"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jrh.12492"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/10463356.2016.11884100"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1051"},{"key":"e_1_2_11_12_1","unstructured":"ORIEN The Orien Difference. 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