{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:57:05Z","timestamp":1790618225013,"version":"4.1.0"},"reference-count":73,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:00:00Z","timestamp":1789776000000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"publisher","award":["12181"],"award-info":[{"award-number":["12181"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Chemotherapy\u2010induced peripheral neuropathy (CIPN) is a common and persistent side effect of chemotherapy, with up to 30% of patients reporting symptoms 6\u00a0months post\u2010treatment. Painful CIPN can impair sleep, mood, and physical functioning. We evaluated \u201cEmbrace Pain,\u201d an online Acceptance and Commitment Therapy (ACT) based self\u2010help intervention that may be of support for cancer survivors with chronic painful CIPN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Embrace Pain Randomized Controlled Trial (RCT) compared ACT with a waiting list condition (WLC) using a two\u2010armed randomized design. Adults (\u2265 18\u00a0years) with painful CIPN \u2265\u00a06\u00a0months post\u2010chemotherapy were randomized to an 8\u2010week guided online ACT program or WLC. Primary outcome was pain interference (Multidimensional Pain Inventory, MPI). Secondary outcomes included pain catastrophizing, psychological flexibility, CIPN severity, pain intensity, and quality of life (QoL). Linear mixed models and criteria for clinically significant change were used to evaluate outcomes from baseline to 3\u2010month follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>112 participants were included (57 ACT, 55 WLC). No significant treatment effect was observed for the primary outcome, pain interference, with ACT not outperforming the WLC over time. However, more ACT participants showed clinically significant improvement in pain interference at 3\u2010month follow\u2010up (47.4% vs. 23.6%) than WLC participants, and exploratory analyses showed greater reductions in pain catastrophizing in the ACT group. No between\u2010group differences were found for psychological flexibility, CIPN severity, pain intensity, or QoL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Online ACT did not demonstrate a significant treatment effect on pain interference in those with painful CIPN. Exploratory findings suggest potential benefits for pain catastrophizing and clinically meaningful improvement in pain interference for some participants. Larger studies are needed to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pon.70608","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T07:45:42Z","timestamp":1789803942000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Embrace Pain<\/i>\n                    \u2014A Randomized Controlled Trial of Online Acceptance and Commitment Therapy for Painful Chemotherapy\u2010Induced Peripheral Neuropathy in Cancer Survivors"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6862-0172","authenticated-orcid":false,"given":"Dani\u00eblle L.","family":"van de Graaf","sequence":"first","affiliation":[{"name":"Department of Medical and Clinical Psychology CoRPS\u2014Center of Research on Psychological Disorders and Somatic Diseases Tilburg University  Tilburg the Netherlands"},{"name":"Tranzo Tilburg School of Social and Behavioral Sciences Tilburg University  Tilburg the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1300-7853","authenticated-orcid":false,"given":"Paul","family":"Lodder","sequence":"additional","affiliation":[{"name":"Department of Medical and Clinical Psychology CoRPS\u2014Center of Research on Psychological Disorders and Somatic Diseases Tilburg University  Tilburg the Netherlands"},{"name":"Department of Methodology and Statistics Tilburg University  Tilburg the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3773-0264","authenticated-orcid":false,"given":"Tom","family":"Smeets","sequence":"additional","affiliation":[{"name":"Department of Medical and Clinical Psychology CoRPS\u2014Center of Research on Psychological Disorders and Somatic Diseases Tilburg University  Tilburg the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1316-7008","authenticated-orcid":false,"given":"Marije L.","family":"van der Lee","sequence":"additional","affiliation":[{"name":"Department of Medical and Clinical Psychology CoRPS\u2014Center of Research on Psychological Disorders and Somatic Diseases Tilburg University  Tilburg the Netherlands"},{"name":"Centre for Psycho\u2010Oncology Scientific Research Department Helen Dowling Institute  Bilthoven the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hester R.","family":"Trompetter","sequence":"additional","affiliation":[{"name":"Department of Medical and Clinical Psychology CoRPS\u2014Center of Research on Psychological Disorders and Somatic Diseases Tilburg University  Tilburg the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karlein M.\u00a0G.","family":"Schreurs","sequence":"additional","affiliation":[{"name":"Department of Psychology, Health &amp; Technology Centre for eHealth &amp; Well\u2010being Research University of Twente  Enschede the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3897-7055","authenticated-orcid":false,"given":"Elin","family":"B\u00f8r\u00f8sund","sequence":"additional","affiliation":[{"name":"Department of Digital Health Research Division of Medicine Oslo University Hospital  Oslo Norway"},{"name":"Department of Nursing and Health Sciences Faculty of Health and Social Sciences University of South\u2010Eastern Norway  Drammen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9261-0871","authenticated-orcid":false,"given":"Lise Solberg","family":"Nes","sequence":"additional","affiliation":[{"name":"Department of Digital Health Research Division of Medicine Oslo University Hospital  Oslo Norway"},{"name":"Department of Psychiatry and Psychology College of Medicine and Science Mayo Clinic  Rochester Minnesota USA"},{"name":"Faculty of Medicine Institute of Clinical Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0818-2913","authenticated-orcid":false,"given":"Floortje","family":"Mols","sequence":"additional","affiliation":[{"name":"Department of Medical and Clinical Psychology CoRPS\u2014Center of Research on Psychological Disorders and Somatic Diseases Tilburg University  Tilburg the Netherlands"},{"name":"Department of Research Netherlands Comprehensive Cancer Organisation (IKNL)  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2014.09.020"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e3282f1a06e"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/pl00007853"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/spc.0b013e328342f9cc"},{"issue":"1","key":"e_1_2_8_6_1","first-page":"18","article-title":"Chemotherapy\u2010Induced Neurotoxicity: The Value of Neuroprotective Strategies","volume":"70","author":"Beijers T.","year":"2012","journal-title":"Netherlands Journal of Medicine"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010014\u20102255\u20107"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24981"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2018.03.052"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2014.11.024"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549\u2010016\u20103939\u20100"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010013\u20101905\u20105"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1188\/10.cjon.e22\u2010e28"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2013.49.1514"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764\u2010021\u201001130\u20107"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304\u20103959(85)90004\u20101"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010020\u201005438\u20105"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186x.2023.2187260"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2005.06.006"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2017.11.009"},{"key":"e_1_2_8_21_1","unstructured":"Society of Clinical Psychology Division 12 A.P.A. 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