{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T05:34:51Z","timestamp":1793165691257,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA236034"],"award-info":[{"award-number":["R01CA236034"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Prior work has identified the protective effects of relationship quality on cancer outcomes. However, less work has focused on how the cancer experience can change relationship quality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To describe neuro\u2010oncology patient\u2010caregiver relationship quality over time and identify the impact of caregiver burden and patient physical and cognitive function on perceptions of relationship quality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a secondary analysis of data obtained at enrollment and 8\u00a0weeks. Actor\u2010partner interdependence models of patient and caregiver ratings of their relationship to each other (Couples Satisfaction Index) over time also included baseline measures of patient cognitive and physical function (Neuro\u2010QOL), caregiver burden (Zarit), and change in these measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Data from 124 neuro\u2010oncology patient\u2010caregiver dyads were analyzed. Relationship quality at both time points, on average, indicated non\u2010distressed relationships, but patients rated relationship quality significantly better than caregivers. Both rated relationship quality significantly worse over time (\n                      <jats:italic>p<\/jats:italic>\n                      values\u00a0&lt;\u00a00.022). At baseline, caregiver burden was significantly negatively associated with patient (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.014) and caregiver relationship quality (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Patient and caregiver baseline relationship quality predicted their own 8\u2010week scores (actor effect;\n                      <jats:italic>p<\/jats:italic>\n                      values\u00a0&lt;\u00a00.001). Baseline patient cognitive function (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.011) and change in patient cognitive function (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.039) were positively associated with 8\u2010week patient relationship quality. Change in caregiver burden was negatively associated with 8\u2010week caregiver relationship quality (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Prior research has largely focused on relationship quality as a resource, but factors associated with the cancer experience may impact perceptions of relationship quality. Lowering caregiver burden may be beneficial to preserving this important coping resource.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pon.70634","type":"journal-article","created":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T18:30:25Z","timestamp":1792348225000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Caregiver Burden and Neuro\u2010Oncology Patient Function: Impacts on Relationship Quality"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3108-465X","authenticated-orcid":false,"given":"Maija","family":"Reblin","sequence":"first","affiliation":[{"name":"Department of Family Medicine University of Vermont  Burlington Vermont USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2194-8787","authenticated-orcid":false,"given":"Deanna","family":"Witte","sequence":"additional","affiliation":[{"name":"Department of Health Outcomes &amp; Behavior Moffitt Cancer Center  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7359-8678","authenticated-orcid":false,"given":"Kristen J.","family":"Wells","sequence":"additional","affiliation":[{"name":"Department of Psychology San Diego State University  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3756-8594","authenticated-orcid":false,"given":"Peter","family":"Forsyth","sequence":"additional","affiliation":[{"name":"Neuro\u2010Oncology Program Moffitt Cancer Center  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8143-4702","authenticated-orcid":false,"given":"Margaret M.","family":"Byrne","sequence":"additional","affiliation":[{"name":"Department of Health Outcomes &amp; Behavior Moffitt Cancer Center  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/nop\/npac053"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2015.00096"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/2882837"},{"key":"e_1_2_10_5_1","first-page":"767","volume-title":"Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy","author":"Loughan A. 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