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For the development of new treatment strategies, it is important to have a detailed picture of LDL nanoparticles on a molecular basis. Through the combination of X\u2010ray and neutron small\u2010angle scattering (SAS) techniques with high hydrostatic pressure (HHP) this study describes structural features of normolipidemic, triglyceride\u2010rich and oxidized forms of LDL. Due to the different scattering contrasts for X\u2010rays and neutrons, information on the effects of HHP on the internal structure determined by lipid rearrangements and changes in particle shape becomes accessible. Independent pressure and temperature variations provoke a phase transition in the lipid core domain. With increasing pressure an interrelated anisotropic deformation and flattening of the particle are induced. All LDL nanoparticles maintain their structural integrity even at 3000 bar and show a reversible response toward pressure variations. The present work depicts the complementarity of pressure and temperature as independent thermodynamic parameters and introduces HHP as a tool to study molecular assembling and interaction processes in distinct lipoprotein particles in a nondestructive manner.<\/jats:p>","DOI":"10.1002\/ppsc.201800149","type":"journal-article","created":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T09:08:59Z","timestamp":1531991339000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["High Hydrostatic Pressure Induces a Lipid Phase Transition and Molecular Rearrangements in Low\u2010Density Lipoprotein Nanoparticles"],"prefix":"10.1002","volume":"35","author":[{"given":"Bernhard","family":"Lehofer","sequence":"first","affiliation":[{"name":"Gottfried Schatz Research Center for Cell Signaling Metabolism and Aging Biophysics Medical University of Graz  Neue Stiftingtalstra\u00dfe 6\/IV 8010 Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maksym","family":"Golub","sequence":"additional","affiliation":[{"name":"Institut Laue\u2010Langevin  71 avenue des Martyrs 38044 Grenoble France"},{"name":"Univ. 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