{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T22:23:45Z","timestamp":1774563825633,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2002,4,1]],"date-time":"2002-04-01T00:00:00Z","timestamp":1017619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Foundation for Pediatric Research, Finland"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Prematurely born infants with neonatal chronic lung disease (CLD) have increased respiratory morbidity and bronchial obstruction at school age. To evaluate the possible inflammatory basis of lung function abnormalities, we studied 40 children, 7.5\u20139.6 years of age, born very prematurely (birth weights, 600\u20131,575 g) and 14 nonatopic term\u2010born controls, using flow\u2010volume spirometry and exhaled nitric oxide (eNO) measurements.<\/jats:p><jats:p>In children born prematurely, eNO was significantly higher in atopics than in nonatopics (respective means, 14.8 vs. 6.3 ppb, <jats:italic>P<\/jats:italic>\u2009=\u20090.02). Nonatopic prematurely born infants did not differ significantly from controls (means, 6.3 vs. 6.4 ppb, <jats:italic>P<\/jats:italic>\u2009=\u2009ns). Of the 27 nonatopic children not on regular glucocorticoid inhalations, 9 had a history of CLD. Spirometry indicated bronchial obstruction and values that were significantly lower in prematurely born infants with or without CLD than in controls, and they were lower in the CLD than the non\u2010CLD group. However, no significant differences were observed in eNO levels between CLD, non\u2010CLD, and control groups (means, 6.8, 5.9, and 6.4 ppb, <jats:italic>P<\/jats:italic>\u2009=\u2009ns).<\/jats:p><jats:p>In nonatopic schoolchildren born very prematurely and with a history of CLD, we found no evidence of airway inflammation associated with increased eNO concentrations. Neither were eNO levels associated with severity of chronic lung disease, as determined by conventional lung function tests. eNO levels were higher in atopic children born prematurely than in controls. Pediatr Pulmonol. 2002; 33:347\u2013355. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.10084","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T23:44:07Z","timestamp":1030319047000},"page":"347-355","source":"Crossref","is-referenced-by-count":23,"title":["Exhaled nitric oxide at school age in prematurely born infants with neonatal chronic lung disease*"],"prefix":"10.1002","volume":"33","author":[{"given":"Suvi T.","family":"Mieskonen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. Pekka","family":"Malmberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Anneli","family":"Kari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna S.","family":"Pelkonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markku T.","family":"Turpeinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. Mikko K.","family":"Hallman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anssi R.A.","family":"Sovij\u00e4rvi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,4]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1542\/peds.90.5.663","article-title":"Improved survival accounts for most, but not all, of the increase in bronchopulmonary dysplasia","volume":"90","author":"Parker RA","year":"1992","journal-title":"Pediatrics"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.82.4.527"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/143.5_Pt_1.1044"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1987.04460070086031"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(98)70220-3"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950080404"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.156.4.9610028"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199012273232603"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.69.1.120"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/fn.81.3.F188"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.93.06091368"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90931-8"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90935-0"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.75.4.323"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)80062-5"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70204-X"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.4.9707143"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(199910)28:4<282::AID-PPUL8>3.0.CO;2-2"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.3.97-05009"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.75.4.319"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/fn.81.3.F217"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.68.5_Spec_No.566"},{"key":"e_1_2_1_24_2","first-page":"730","article-title":"Prenatal dexamethasone treatment in conjunction with rescue therapy of human surfactant: a randomized placebo\u2010controlled multicenter study","volume":"93","author":"Kari MA","year":"1994","journal-title":"Pediatrics"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1990.tb11503.x"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.152.3.7663792"},{"key":"e_1_2_1_27_2","first-page":"42","volume-title":"Pulmonary function testing in children: technics and standards","author":"Polgar G","year":"1971"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.97.10071683"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.152.3.7663801"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00014314"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.6.ats8-99"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.155.1.9001322"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.48.10.1034"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.1.9804134"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.1999.13f25.x"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3038.2000.00093.x"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(93)90078-T"},{"key":"e_1_2_1_38_2","first-page":"631","article-title":"Cytologic evaluation of pulmonary effluent in neonates with respiratory distress syndrome and bronchopulmonary dysplasia","volume":"25","author":"Merritt TA","year":"1981","journal-title":"Acta Cytol"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.10084","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.10084","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T13:12:02Z","timestamp":1700399522000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.10084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,5]]}},"alternative-id":["10.1002\/ppul.10084"],"URL":"https:\/\/doi.org\/10.1002\/ppul.10084","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,4]]}}}