{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T07:57:15Z","timestamp":1791014235408,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2002,4,1]],"date-time":"2002-04-01T00:00:00Z","timestamp":1017619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Early detection of hepatopulmonary syndrome (HPS) may be delayed because of invasiveness of the diagnostic procedures. In this pilot study, we prospectively investigated the usefulness of determining transcutaneous O<jats:sub>2<\/jats:sub> tension after 100% O<jats:sub>2<\/jats:sub> (TcPO<jats:sub>2<\/jats:sub>100) breathing using a transcutaneous hyperoxia test (THT) in 11 children with chronic cholestasis and without primary cardiopulmonary disease. These patients also underwent alveolar\u2010arterial O<jats:sub>2<\/jats:sub> gradient testing (AaDO<jats:sub>2<\/jats:sub>) at an inspired oxygen fraction (FiO<jats:sub>2<\/jats:sub>) of 0.21, lung scintiscan, and contrast transthoracic echocardiography (TTE). Three of them had a liver transplantation because of the downhill course of their liver disease and respiratory status.<\/jats:p><jats:p>THT transcutaneous O<jats:sub>2<\/jats:sub> tension at 21% FiO<jats:sub>2<\/jats:sub> (TcPO<jats:sub>2<\/jats:sub>21) was 75\u2009\u00b1\u200913 mmHg, and increased to 488\u2009\u00b1\u2009106 mmHg after 100% O<jats:sub>2<\/jats:sub> breathing (TcPO<jats:sub>2<\/jats:sub>100). Both mean values were not significantly different from those found in 8 age\u2010matched controls (<jats:italic>P<\/jats:italic>\u2009=\u20090.9 and <jats:italic>P<\/jats:italic>\u2009=\u20090.5, respectively). However, one patient, in spite of her stable liver function, showed an abnormal TcPO<jats:sub>2<\/jats:sub>21 and TcPO<jats:sub>2<\/jats:sub>100 (45 mmHg and 210 mmHg, respectively). This same subject was also the only patient with abnormalities of AaDO<jats:sub>2<\/jats:sub> (54.2 mmHg; normal value, &lt;\u200920 mmHg), lung scintiscan (brain\/lung ratio of technetium\u201099 fixation (B\/L SI)\u2009=\u20099, normal value &lt;\u20091), and TTE, suggesting intrapulmonary vasodilatations and shunts. Given the clinical development of cyanosis and platypnea, all criteria for HPS were fulfilled, and timing of her liver transplantation was therefore accelerated. This resulted in HPS regression.<\/jats:p><jats:p>In children with chronic cholestasis, repeated transcutaneous bedside measurements are a rapid and reliable noninvasive test for characterizing the severity of abnormal oxygenation, and may prove useful also in liver posttransplantation monitoring. Pediatr Pulmonol. 2002; 33:374\u2013379. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.10088","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T23:44:07Z","timestamp":1030319047000},"page":"374-379","source":"Crossref","is-referenced-by-count":22,"title":["Noninvasive investigation of hepatopulmonary syndrome in children and adolescents with chronic cholestasis"],"prefix":"10.1002","volume":"33","author":[{"given":"Francesca","family":"Santamaria","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Sarnelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Celentano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Farina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Vegnente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Mansi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Montella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Vajro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,4]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.46.1.1"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2000.7519"},{"key":"e_1_2_1_4_2","first-page":"209","article-title":"Per\u2010rectal portal scintigraphy is complementary to ultrasonography and endoscopy in the evaluation of portal hypertension in children followed\u2010up for chronic cholestasis","volume":"26","author":"Vajro P","year":"1997","journal-title":"Hepatology"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0272-5231(21)00625-0","article-title":"Noninvasive monitoring of oxygen and carbon dioxide","volume":"10","author":"Wiedmann HP","year":"1989","journal-title":"Clin Chest Med"},{"key":"e_1_2_1_6_2","first-page":"287","article-title":"Determination of capillary oxygen tension in infants and children. 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