{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:21:58Z","timestamp":1789471318907,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2002,7,1]],"date-time":"2002-07-01T00:00:00Z","timestamp":1025481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2002,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to evaluate cytokine secretion in children with acute <jats:italic>Mycoplasma pneumoniae<\/jats:italic> infection and wheeze. We studied 25 patients aged 2\u201314 years with an acute episode of wheezing (15 with acute <jats:italic>M. pneumoniae<\/jats:italic> infection) and 16 healthy controls of similar gender and age (8 with laboratory evidence of asymptomatic acute <jats:italic>M. pneumoniae<\/jats:italic> infection). Serum interleukin (IL)\u20102, interferon (IFN)\u2010\u03b3, IL\u20104, and IL\u20105 concentrations were measured in samples obtained at enrollment, using enzyme\u2010linked immunosorbent assay kits.<\/jats:p><jats:p>In the presence of wheezing, IL\u20105 concentrations were significantly higher in subjects with acute <jats:italic>M. pneumoniae<\/jats:italic> infection (33.415\u2009\u00b1\u200922.138 pg\/mL) than in those without such infection (2.320\u2009\u00b1\u20091.846 pg\/mL, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). The children with acute <jats:italic>M. pneumoniae<\/jats:italic> infection and wheeze had higher IL\u20105 concentrations (33.415\u00b122.138 pg\/mL) than those with asymptomatic acute infection and without wheeze (1.740\u2009\u00b1\u20092.299 pg\/mL, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). No significant between\u2010group differences were observed in terms of IL\u20102, IFN\u2010\u03b3, or IL\u20104 levels, or the prevalence of atopy.<\/jats:p><jats:p>Our results show that children with wheezing and acute <jats:italic>M. pneumoniae<\/jats:italic> infection have a specific cytokine profile characterized by a significant increase in serum levels of IL\u20105. This immune response may be important for understanding the pathophysiological mechanisms by which this pathogen contributes to the development of wheeze\u2010related symptoms, and for identifying new treatment strategies. Pediatr Pulmonol. 2002; 34:122\u2013127. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.10139","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T11:42:41Z","timestamp":1033904561000},"page":"122-127","source":"Crossref","is-referenced-by-count":56,"title":["Cytokine secretion in children with acute <i>Mycoplasma pneumoniae<\/i> infection and 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