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By 16 weeks of gestation the presence of severe oligohydramnios in one twin had resulted in renal agenesis, but not in the other twin, who did not have oligohydramnios. By 20 weeks of gestation, the two amniotic fluid volumes had become the same in both twins. At 33 weeks, the twins were delivered by cesarean section. Despite intensive respiratory care, the twin with renal agenesis died from severe pneumomediastinum on day 3. At autopsy, pulmonary hypoplasia was demonstrated in that twin. This experiment of nature demonstrates that oligohydramnios during the early canalicular stage of pulmonary development (gestational age, 16\u201320 weeks) may be pathogenically important in pulmonary hypoplasia. Pediatr Pulmonol. 2002; 34:218\u2013221. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.10151","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T12:19:07Z","timestamp":1033906747000},"page":"218-221","source":"Crossref","is-referenced-by-count":1,"title":["Pulmonary hypoplasia with an unusual prenatal history"],"prefix":"10.1002","volume":"34","author":[{"given":"Ritsuko","family":"Takahashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyuki","family":"Kakizawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Itow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shingi","family":"Nakae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Shintaku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michio","family":"Nagata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,8,14]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(46)80241-5"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320190408"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.54.1.32"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(74)80608-6"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(74)80753-5"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)81092-0"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/S0022-5347(17)35169-8","article-title":"Prenatal and postnatal findings in monochorionic, monoamniotic, twins discordant for bilateral renal agenesis\u2010dysgenesis (perinatal lethal renal disease)","volume":"151","author":"Cliento BG","year":"1994","journal-title":"J Urol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(94)00249-D"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19971128)73:1<76::AID-AJMG15>3.0.CO;2-O"},{"key":"e_1_2_1_11_2","first-page":"872","article-title":"Amnioinfusions in renal agenesis","volume":"83","author":"Cameron D","year":"1994","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1066525"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1986.02140170051027"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)90772-Y"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.3109\/15513818709161415"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.1992.263.3.L376"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.11.3.8086163"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(94)70156-3"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(95)00195-W"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198610000-00012"},{"key":"e_1_2_1_21_2","first-page":"441","article-title":"Potter's syndrome associated with renal agenesis or dysplasia. 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