{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T02:29:25Z","timestamp":1771036165672,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,12,2]],"date-time":"2002-12-02T00:00:00Z","timestamp":1038787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Infant diaphragm function may be adversely affected in a variety of disorders and conditions. Key to establishing an accurate diagnosis are appropriate control data. The aim of this study was to determine the effect of maturation on diaphragm function, using a nonvolitional test. Diaphragm function was assessed by measuring the transdiaphragmatic pressure (Pdi) generated by magnetic stimulation of the phrenic nerves. Ballon catheters were positioned in the lower third of the esophagus and stomach. Esophageal (Pes) and gastric (Pgas) pressure changes were measured using differential pressure transducers. The pressure signals were amplified and displayed in real time on a computer (running Labview\u2122 software) and Pdi derived by online subtraction of Pes from Pgas.<\/jats:p><jats:p>Twenty\u2010nine infants (14 born preterm), at a median gestational age of 37 (range, 25\u201342) weeks, were studied at a median postconceptional age (PCA) of 39 (range, 32\u201344) weeks. At time of measurement, none had respiratory problems or were hyperinflated (functional residual capacity ranged from 23\u201335 mL\/kg). The preterm infants had significantly lower transdiaphragmatic pressures responses following median left (4.0, range 2.5\u20136.8 cmH<jats:sub>2<\/jats:sub>O vs. 4.8, range 2.8\u20137.2 cmH<jats:sub>2<\/jats:sub>O) and median right phrenic nerve stimulation (3.6, range 2.6\u20134.8 cmH<jats:sub>2<\/jats:sub>O vs. 4.3, range 2.7\u20136.8 cmH<jats:sub>2<\/jats:sub>O) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) than term infants. Following left and right phrenic nerve stimulation, Pdi correlated significantly with gestational age (r\u2009=\u20090.4, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05, and r\u2009=\u20090.4, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05, respectively) and PCA (r\u2009=\u20090.37, <jats:italic>P<\/jats:italic>\u2009=\u20090.05, and r\u2009=\u20090.56, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01, respectively).<\/jats:p><jats:p>We conclude that gestational age at birth and postconceptional age at time of measurements must be taken into account when interpreting the results of infant diaphragm function tests. Pediatr Pulmonol. 2003; 35:17\u201322. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.10209","type":"journal-article","created":{"date-parts":[[2002,12,3]],"date-time":"2002-12-03T13:53:35Z","timestamp":1038923615000},"page":"17-22","source":"Crossref","is-referenced-by-count":23,"title":["Influence of maturation on infant diaphragm function assessed by magnetic stimulation of phrenic nerves"],"prefix":"10.1002","volume":"35","author":[{"given":"Gabriel","family":"Dimitriou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Greenough","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Moxham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerrard F.","family":"Rafferty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,12,2]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1978.44.6.909"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-3782(99)00075-4"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.3.2004176"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/fn.80.1.F8"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.49.12.1234"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.6.2004019"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/fn.72.3.F180"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1969.sp008710"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(199604)21:4<250::AID-PPUL9>3.0.CO;2-S"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(93)90026-H"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198309000-00003"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-197911000-00001"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1152\/jappl.1983.55.2.353","article-title":"Influence of chest wall distortion on esophageal pressure","volume":"55","author":"LeSou\u00ebf PN","year":"1983","journal-title":"J Appl Physiol"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198607000-00016"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198710000-00018"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)83368-2"},{"key":"e_1_2_1_18_2","first-page":"1332","article-title":"Phrenic nerve stimulation at the bedside in children equipment and validation","volume":"6","author":"Ross Russell RI","year":"1993","journal-title":"Eur J Pediatr"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.50.11.1162"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1986.61.3.1153"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.44.12.990"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.10209","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.10209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T16:31:29Z","timestamp":1700238689000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.10209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,12,2]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,1]]}},"alternative-id":["10.1002\/ppul.10209"],"URL":"https:\/\/doi.org\/10.1002\/ppul.10209","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,12,2]]}}}