{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T22:12:35Z","timestamp":1774563155159,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2003,4,3]],"date-time":"2003-04-03T00:00:00Z","timestamp":1049328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2003,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to compare in atopic and nonatopic asthmatic children correlations between two inflammation parameters, i.e., blood eosinophilia and exhaled nitric oxide (FE<jats:sub>NO<\/jats:sub>), and pulmonary function values, at baseline and after \u03b2<jats:sub>2<\/jats:sub>\u2010adrenergic bronchodilators. Ninety\u2010two steroid\u2010naive asthmatic children were evaluated: 26 were skin prick test\u2010 and RAST\u2010negative (nonatopic subjects), whereas 66 were atopic, 15 being sensitized only to house dust mites (monosensitized) and 51 to mites and to at least one other class of allergens (polysensitized). Baseline spirometric values (FEV<jats:sub>1<\/jats:sub> and FEF<jats:sub>25\u201375%<\/jats:sub>) were similar in atopic and nonatopic groups (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.1, each comparison). However, when compared to nonatopic subjects, atopic children showed a significantly higher degree of blood eosinophilia (3.0% and 6.7% white blood cell count, respectively; <jats:italic>P<\/jats:italic>\u2009=\u20090.0001) and higher FE<jats:sub>NO<\/jats:sub> levels (6.8 ppb and 16.0 ppb, respectively; <jats:italic>P<\/jats:italic>\u2009=\u20090.0001). While a positive correlation between FE<jats:sub>NO<\/jats:sub> levels and blood eosinophilia was observed in atopic children (r\u2009=\u20090.25, <jats:italic>P<\/jats:italic>\u2009=\u20090.041), no correlations between these two inflammation parameters and baseline pulmonary function values were demonstrated in any of the asthmatic groups. Inhalation of a \u03b2<jats:sub>2<\/jats:sub>\u2010agonist drug induced in the two asthmatic populations similar improvements in FEV<jats:sub>1<\/jats:sub> and FEF<jats:sub>25\u201375%<\/jats:sub> and no changes in FE<jats:sub>NO<\/jats:sub> levels or blood eosinophilia. However, only in atopic children positive correlations were found between percent variation in FEV<jats:sub>1<\/jats:sub> (\u0394%FEV<jats:sub>1<\/jats:sub>) and FE<jats:sub>NO<\/jats:sub> levels (r\u2009=\u20090.35, <jats:italic>P<\/jats:italic>\u2009=\u20090.006) or blood eosinophilia (r\u2009=\u20090.26, <jats:italic>P<\/jats:italic>\u2009=\u20090.04). Within the atopic group, no differences were found between mono\u2010 and polysensitized individuals in all parameters evaluated. Thus only in atopic children did parameters of inflammation correlate with airway obstruction reversibility. Pediatr Pulmonol. 2003; 35:358\u2013363. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.10264","type":"journal-article","created":{"date-parts":[[2003,4,7]],"date-time":"2003-04-07T15:03:25Z","timestamp":1049727805000},"page":"358-363","source":"Crossref","is-referenced-by-count":47,"title":["Correlations between exhaled nitric oxide levels, blood eosinophilia, and airway obstruction reversibility in childhood asthma are detectable only in atopic individuals"],"prefix":"10.1002","volume":"35","author":[{"given":"Michela","family":"Silvestri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Sabatini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Sale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna\u2010Carla","family":"Defilippi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Fregonese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Battistini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio G.","family":"Biraghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni A.","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,4,3]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(91)90408-G"},{"key":"e_1_2_1_3_2","unstructured":"National Asthma and Education Prevention Program. Expert panel report 2.Guidelines for the diagnosis and management of asthma. National Institutes of Health. July 1997. National Heart Lung and Blood Institute. NIH publication no. 97\u20104051."},{"key":"e_1_2_1_4_2","first-page":"1683","article-title":"Airway eosinophilic inflammation, epithelial damage and bronchial hyperresponsiveness in patients with mild\u2010moderate stable asthma","volume":"10","author":"Oddera S","year":"1996","journal-title":"Allergy"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.1.9703002"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1152\/jappl.1990.69.6.2209","article-title":"Allergen\u2010induced increase in airway responsiveness and inflammation in mild asthma","volume":"69","author":"Brusasco V","year":"1990","journal-title":"J Appl Physiol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.7.2009041"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1711.2001.00990.x"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(95)80128-6"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.56.5.333"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.56.5.345"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.1999.13b17.x"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/1099-0496(200011)30:5<385::AID-PPUL4>3.0.CO;2-#"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.5.2012125"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.1999.14d28.x"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.56.11.857"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.6.ats8-99"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.313.7059.744"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.3.16134"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.1.ed-19"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.91.3.1029"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.6.484"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3038.2001.012003125.x"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.10264","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.10264","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T16:52:17Z","timestamp":1700239937000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.10264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4,3]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2003,5]]}},"alternative-id":["10.1002\/ppul.10264"],"URL":"https:\/\/doi.org\/10.1002\/ppul.10264","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,4,3]]}}}