{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T04:45:07Z","timestamp":1789447507617,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2001,3,22]],"date-time":"2001-03-22T00:00:00Z","timestamp":985219200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2001,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to define the inflammatory changes occurring in the lungs of infants at risk for bronchopulmonary dysplasia (BPD) over the first 28 days of life, and to define an optimal strategy for steroids therapy in the prevention of BPD. We measured levels of interleukin\u20106 (IL\u20106) and interleukin\u20101 beta (IL\u20101\u03b2) in tracheal aspirate (TA) samples and blood of premature infants with severe respiratory distress syndrome RDS (n\u2009=\u200945) on the first day of life prior to initiation of surfactant therapy and on days 5\u20137, 12\u201314, 19\u201321, and 26\u201328. Levels of IL\u20106 and IL\u20101\u03b2 were determined with a commercially available enzyme\u2010linked immunoassay. Logistic regression analyses were performed in order to examine differences in trends in levels of IL\u20106 and IL\u20101\u03b2 between groups of infants. Infants were divided into group I (n\u2009=\u200930, FiO<jats:sub>2<\/jats:sub>\u2009\u2264\u20090.35 at 28 days) and group II (n\u2009=\u200915, FiO<jats:sub>2<\/jats:sub>\u2009&gt;\u20090.35 based on their likelihood of developing BPD at 36 weeks postconceptional age (PCA).<\/jats:p><jats:p>The infants were comparable with respect to mean (\u2009\u00b1\u2009SEM) birth weight (895\u2009\u00b1\u200933 g vs. 900\u2009\u00b1\u200940 g), gestational age (27\u2009\u00b1\u20090.38 weeks vs. 27\u2009\u00b1\u20090.54 weeks), and severity of respiratory illness at entry into the study (mean airway pressure: 12\u2009\u00b1\u20091 cmH<jats:sub>2<\/jats:sub>O vs. 12\u2009\u00b1\u20091 cmH<jats:sub>2<\/jats:sub>O, and oxygen index: 15\u2009\u00b1\u20092 vs. 19\u2009\u00b1\u20094) (group I vs. group II, respectively). Logistic regression analyses failed to reveal any significant differences in linear trends of levels of IL\u20106 and IL\u20101\u03b2 in TA samples between both groups of infants. No particular pattern of change in levels of IL\u20106 or IL\u20101\u03b2 could be identified among groups of infants. Levels of IL\u20106 and IL\u20101\u03b2 in TA samples on the first day of life failed to predict the need for FiO<jats:sub>2<\/jats:sub>\u2009&gt;\u20090.35 at 28 days of age.<\/jats:p><jats:p>We could not identify an increasing trend or a specific pattern of changes in postnatal levels of IL\u20106 or IL\u20101\u03b2 in TA samples of infants who were at greater risk of developing BPD at 36 weeks PCA compared to infants who were not. Pediatr Pulmonol. 2001; 31:220\u2013226. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.1032","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T21:30:12Z","timestamp":1030311012000},"page":"220-226","source":"Crossref","is-referenced-by-count":22,"title":["Serial changes in levels of IL\u20106 and IL\u20101\u03b2 in premature infants at risk for bronchopulmonary dysplasia*"],"prefix":"10.1002","volume":"31","author":[{"given":"S. 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