{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T13:46:33Z","timestamp":1760622393884},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2003,8,4]],"date-time":"2003-08-04T00:00:00Z","timestamp":1059955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Our objective was to compare the effectiveness of maximum forced expiratory flow measured at functional residual capacity (V\u2032maxFRC) and the ratio of flow at 75% of the forced expiratory volume to peak forced expiratory flow (FEF<jats:sub>75<\/jats:sub>\/FEF<jats:sub>peak<\/jats:sub>) for detecting bronchodilator\u2010related changes in wheezy infants. In 55 infants (mean age, 7.8\u2009\u00b1\u20093.1 months) with a history of recurrent wheezing, V\u2032maxFRC and FEF<jats:sub>75<\/jats:sub>\/FEF<jats:sub>peak<\/jats:sub> were measured at baseline and 15 min following nebulized albuterol. Mean results from 4 baseline and 4 postalbuterol partial expiratory flow\u2010volume curves were compared at baseline and following bronchodilator challenge. The strength (relative effect size) of each measure for assessing change was quantified by dividing the mean of the pre\u2010 to postdifferences by the standard deviation of the differences. Mean percent predicted V\u2032maxFRC was 41.3\u2009\u00b1\u200934.3% at baseline and 44.4\u2009\u00b1\u200934.0% following albuterol. Mean FEF<jats:sub>75<\/jats:sub>\/FEF<jats:sub>peak<\/jats:sub> was 26.7\u2009\u00b1\u200913.4% at baseline and 35.8\u2009\u00b1\u200914.3% following albuterol. The mean percent change from baseline [(post\u2010pre)\/pre] in percent predicted V\u2032maxFRC was 18.3\u2009\u00b1\u200939.3, and for FEF<jats:sub>75<\/jats:sub>\/FEF<jats:sub>peak<\/jats:sub>, it was 44.1\u2009\u00b1\u200936.8. The change in FEF<jats:sub>75<\/jats:sub>\/FEF<jats:sub>peak<\/jats:sub> following albuterol was significantly greater than the change in V\u2032maxFRC (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). The relative effect size for mean percent change from baseline in V\u2032maxFRC was 0.47, and for FEF<jats:sub>75<\/jats:sub>\/FEF<jats:sub>peak<\/jats:sub>, 1.20. Changes in FEF<jats:sub>75<\/jats:sub>\/FEF<jats:sub>peak<\/jats:sub> appear to differentiate changes in airway function following administration of a bronchodilator better than do changes in V\u2032maxFRC. Pediatr Pulmonol. 2003; 36:196\u2013201. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.10325","type":"journal-article","created":{"date-parts":[[2003,8,6]],"date-time":"2003-08-06T12:50:10Z","timestamp":1060174210000},"page":"196-201","source":"Crossref","is-referenced-by-count":2,"title":["Assessing bronchodilator responsiveness in infants using partial expiratory flow\u2010volume 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