{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T23:10:52Z","timestamp":1774566652048,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2003,8,22]],"date-time":"2003-08-22T00:00:00Z","timestamp":1061510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2003,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objective of this study was to identify wheezing recurrences and related risk factors in two groups of infants with bronchiolitis: respiratory syncytial virus (RSV) (+) and RSV (\u2212) as determined by RSV enzyme immunoassay. A 1\u2010year prospective cohort study was conducted with infants younger than 2 years old. Follow\u2010up was made monthly, by a clinical visit and\/or by telephone, checking the number of wheezing episodes per month and possible related risk factors. There were 96 subjects enrolled, of whom 77 reached complete follow\u2010up: 36 were RSV (+) (46.8%), and 41 were RSV (\u2212) (53.2%). In the RSV (+) group, there were 17 males (47%), vs. RSV (\u2212) with 30 males (73%) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05); 22 RSV (+) (61%) were admitted to hospital, vs.14 RSV (\u2212) (34%) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Mean age was not significantly different in both groups. The mean number of recurrences was 3.36 episodes\/infant\/year in the RSV (+) and 2.34 in the RSV (\u2212) group (<jats:italic>P<\/jats:italic>\u2009=\u20090.06). Crude relative risk (RR) for a new recurrence of an obstructive episode was 1.33 (95% CI, 0.99\u20131.79). After adjustment for several potential confounders, the RR was 1.41 (95% CI, 1.03\u20131.93). Hospitalization stay was longer in the RSV (+) than the RSV (\u2212) group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). In the RSV (+) group, patients who had been hospitalized showed more recurrences (4.18) than those with outpatient treatment (2.07) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05); this difference did not exist in the RSV (\u2212) group. The related risk factors for recurrent wheeze in the RSV (\u2212) group were male gender, number of siblings, and daycare attendance (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). In the RSV (+) group, the risk of recurrent wheeze was only increased by admission to hospital during the acute bronchiolitis episode (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). We speculate that there may be a higher rate of increased airway reactivity and\/or preexisting diminished lung function in RSV (+) infants requiring hospitalization for their initial illness. In conclusion, RSV\u2010proven bronchiolitis, particularly in those infants who are hospitalized, is associated with a higher recurrence of wheezing episodes in the subsequent 12 months. Other factors appear to account for recurrent wheeze in the RSV (\u2212) group. Pediatr Pulmonol. 2003; 36:316\u2013321. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.10365","type":"journal-article","created":{"date-parts":[[2003,8,26]],"date-time":"2003-08-26T15:26:55Z","timestamp":1061911615000},"page":"316-321","source":"Crossref","is-referenced-by-count":15,"title":["Risk factors for recurrent wheezing following acute bronchiolitis: A 12\u2010month follow\u2010Up"],"prefix":"10.1002","volume":"36","author":[{"given":"Lorena","family":"Cifuentes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solange","family":"Caussade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Villagr\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Darrigrande","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Bedregal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gonzalo","family":"Valdivia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,8,25]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1020-49891997000100003"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199603000-00011"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.1996.tb00099.x"},{"key":"e_1_2_1_5_2","first-page":"13","article-title":"Viral antigens in nasopharyngeal exudates from infants with acute lower respiratory tract infections","volume":"63","author":"Boza ML","year":"1992","journal-title":"Rev Chil Pediatr"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.4067\/S0370-41061992000500004"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199108000-00003"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01957564"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.3.9801052"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)10321-5"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950070307"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.106.3.e38"},{"key":"e_1_2_1_13_2","first-page":"625","article-title":"Predicting clinically significant lower respiratory tract illness in childhood following mild bronchiolitis","volume":"139","author":"McConnochie KM","year":"1985","journal-title":"Am J Dis Child"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.5.9906076"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.284.6330.1665"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.5.9904078"},{"key":"e_1_2_1_17_2","first-page":"28","article-title":"Pulmonary function changes in children after respiratory syncytial virus in infancy","volume":"135","author":"McBride JT","year":"1999","journal-title":"J Pediatr"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/151.5_Pt_1.1678"},{"key":"e_1_2_1_19_2","first-page":"8","article-title":"Epidemiologic evidence of increased airway reactivity in children with a history of bronchiolitis","volume":"135","author":"Kattan M","year":"1999","journal-title":"J Pediatr"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6104.11"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199501193320301"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/151.5_Pt_1.1644"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.10365","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.10365","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T17:11:39Z","timestamp":1700241099000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.10365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,8,25]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003,10]]}},"alternative-id":["10.1002\/ppul.10365"],"URL":"https:\/\/doi.org\/10.1002\/ppul.10365","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,8,25]]}}}