{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T20:43:45Z","timestamp":1775508225209,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2003,9,25]],"date-time":"2003-09-25T00:00:00Z","timestamp":1064448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We measured exhaled nitric oxide and tracheal aspirate endothelin\u20101 to determine relationships between these substances and alterations in pulmonary gas exchange during respiratory distress syndrome (RDS) in comparison to those obtained from control preterm infants without RDS. Eight infants with RDS had measurements made at 24 hr and again at 48\u201372 hr. Eight control infants were studied once at 24\u201348 hr of life. Exhaled gas was analyzed on\u2010line, and minute excretion of NO (V\u0307<jats:sub>NO<\/jats:sub>) was calculated. ET\u20101 was determined by immunoassay. Median V\u0307<jats:sub>NO<\/jats:sub> at 24 hr in RDS was 0.405 nl\/min\/kg (range, 0.30 \u20130.79), which subsequently declined by 48\u201372 hr to 0.166 nl\/min\/kg (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). The V\u0307<jats:sub>NO<\/jats:sub> in RDS infants was significantly higher than time\u2010matched V\u0307<jats:sub>NO<\/jats:sub> in controls, with a median of 0.099 nl\/min\/kg (range, 0.03\u20130.27; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). ET\u20101 was not correlated with initial V\u0307<jats:sub>NO<\/jats:sub> in the RDS or control patients. In conclusion, in RDS, V\u0307<jats:sub>NO<\/jats:sub> decreases as gas exchange improves. ET\u20101 is detectable in tracheal aspirate samples in both groups of infants. Pediatr Pulmonol. 2003; 36:421\u2013426. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.10371","type":"journal-article","created":{"date-parts":[[2003,9,26]],"date-time":"2003-09-26T10:39:45Z","timestamp":1064572785000},"page":"421-426","source":"Crossref","is-referenced-by-count":10,"title":["Exhaled nitric oxide and tracheal endothelin\u20101 in preterm infants with and without RDS"],"prefix":"10.1002","volume":"36","author":[{"given":"Steven L.","family":"Olsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Perry L.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald W.","family":"Thibeault","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mike","family":"Norberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William 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