{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T13:47:51Z","timestamp":1761486471248},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2001,3,29]],"date-time":"2001-03-29T00:00:00Z","timestamp":985824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2001,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Our objective was to describe the respiratory complications, clinical findings, and chest radiographic changes in the first year of life in infected and uninfected children born to HIV\u20101\u2010infected women. We prospectively followed a cohort of 600 infants born to HIV\u20101\u2010infected women from birth to 12 months in a multicenter study. Of these, 93 infants (15.5%) were HIV\u20101\u2010infected, 463 were uninfected, and 44 were of unknown status prior to death or loss to follow\u2010up.<\/jats:p><jats:p>The cumulative incidence (\u2009\u00b1\u2009SE) of an initial pneumonia episode at 12 months was 24.1\u2009\u00b1\u20094.7% in HIV\u20101\u2010infected children compared to 1.4\u2009\u00b1\u20090.6% in HIV\u20101\u2010uninfected children (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The rate of <jats:italic>Pneumocystis carinii<\/jats:italic> pneumonia (PCP) was 9.5 per 100 child\u2010years. The HIV\u20101 RNA load was not higher in the group that developed pneumonia in the first year vs. those who did not. Children who developed lower respiratory tract infections or PCP had increased rates of decline of CD4 cell counts during the first 6 months of life. Lower maternal CD4 cell counts were associated with higher rates of pneumonia, and upper and lower respiratory tract infections. The rates of upper respiratory tract infection and bronchiolitis\/reactive airway disease in infected children were not significantly different than in uninfected children. At 12 months, significantly more HIV\u20101\u2010infected than uninfected children had tachypnea and chest radiographs with nodular and reticular densities. There was no relationship between cytomegalo virus infection in the first year of life and radiographic changes or occurrences of pneumonia.<\/jats:p><jats:p>In conclusion, despite a low incidence of PCP, rates of pneumonia remain high in HIV\u2010infected children in the first year of life. The incidence of pneumonia in uninfected infants born to HIV\u20101\u2010infected mothers is low. Chest X\u2010ray abnormalities and tachypnea suggest that subacute disease is present in infected infants. Further follow\u2010up is warranted to determine its nature. Pediatr Pulmonol. 2001; 31:267\u2013276. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.1038","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T21:28:49Z","timestamp":1030310929000},"page":"267-276","source":"Crossref","is-referenced-by-count":16,"title":["Respiratory diseases in the first year of life in children born to HIV\u20101\u2010infected women*"],"prefix":"10.1002","volume":"31","author":[{"given":"Meyer","family":"Kattan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnold","family":"Platzker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert B.","family":"Mellins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark D.","family":"Schluchter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin 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