{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T22:29:53Z","timestamp":1774564193944,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,1,12]],"date-time":"2004-01-12T00:00:00Z","timestamp":1073865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2004,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Our objective was to evaluate the efficacy and safety of two doses of fluticasone propionate (FP) in young children with recurrent wheezing and risk factors for asthma. Our study design was a randomized, double\u2010blind, placebo\u2010controlled comparison of inhaled FP 50 mcg twice daily (FP 100) and 125 mcg twice daily (FP 250), for 6 months. Outcome measures included number of wheezing episodes, days on albuterol, height standard deviation score (height SDS), osteocalcin (OC), bone alkaline phosphatase fraction (AKP), insulin\u2010like growth factor\u2010binding protein 3 (IGFBP\u20103), and serum levels of cortisol (SC). Our subjects were 30 patients, aged 7\u201324 months. Mean wheezing episodes were 6.0\u2009\u00b1\u20091.9, 1.9\u2009\u00b1\u20091.9, and 2.8\u2009\u00b1\u20091.2; mean days of albuterol use were 24.3\u2009\u00b1\u20091.3, 6.5\u2009\u00b1\u20090.8, and 9.1\u2009\u00b1\u20090.8, per patient for placebo, FP100, and FP250 groups, respectively. There was a significant reduction in clinical outcome in the two FP groups compared to placebo (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). No significant correlations were found between FP dosage and height SDS, OC, AKP, IGFBP\u20103, and SC. In conclusion, in young children with asthmatic symptoms, FP at 50 and 125 mcg b.i.d. for 6 months significantly improved respiratory symptoms without causing significant side effects on growth and bone metabolism. Pediatr Pulmonol. 2004; 37:111\u2013115. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.10400","type":"journal-article","created":{"date-parts":[[2004,1,13]],"date-time":"2004-01-13T12:01:44Z","timestamp":1073995304000},"page":"111-115","source":"Crossref","is-referenced-by-count":45,"title":["Effects of inhaled fluticasone propionate in children less than 2 years old with recurrent wheezing"],"prefix":"10.1002","volume":"37","author":[{"given":"Alejandro M.","family":"Teper","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro J.","family":"Colom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos D.","family":"Kofman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto F.","family":"Maffey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago M.","family":"Vidaurreta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Bergad\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,1,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199501193320301"},{"key":"e_1_2_1_3_2","volume-title":"Global initiative for asthma: global strategy for asthma management and prevention","author":"NIH, NHLBI","year":"1995"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.71.4.331"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)05333-6"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/148.4_Pt_2.S1"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)92147-A"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.69.3.351"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.85.2.143"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.118789"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950090310"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.73.4.327"},{"key":"e_1_2_1_13_2","first-page":"151","article-title":"Clinical longitudinal standards for height, weight, height velocity, weight velocity and stages of puberty","volume":"9","author":"Tanner JM","year":"1976","journal-title":"Arch Dis Child"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0954-6111(94)90044-2"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70405-1"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1996.tb13989.x"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.1.9811024"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.67.6.703"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.61.11.1049"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199312023292305"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.303.6795.163"},{"key":"e_1_2_1_22_2","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1542\/peds.89.5.839","article-title":"Controlled study of linear growth in asthmatic children during treatment with inhaled glucocorticosteroids","volume":"89","author":"Wolthers OD","year":"1992","journal-title":"Pediatrics"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)90310-8"},{"key":"e_1_2_1_24_2","first-page":"316","article-title":"Growth of asthmatic children","volume":"303","author":"Mackenzie CA","year":"1991","journal-title":"Br Med J [Clin Res]"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.71.5.409"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1360525"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950160604"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.302.6777.627"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90058-W"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(06)80116-2"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(92)90106-C"},{"key":"e_1_2_1_32_2","first-page":"2971","article-title":"Procollagen propeptide and pyridinium cross\u2010links as markers of type I collagen turnover: sex and age related changes in healthy children","volume":"82","author":"Zanze M","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.7.2056"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.10400","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.10400","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T02:29:25Z","timestamp":1700274565000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.10400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1,12]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,2]]}},"alternative-id":["10.1002\/ppul.10400"],"URL":"https:\/\/doi.org\/10.1002\/ppul.10400","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,1,12]]}}}