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We used immunohistochemistry to evaluate IGF\u20101 and IGF\u2010R expression in lungs from autopsies of human stillbirths and RDS and BPD patients. IGF\u20101 and IGF\u2010R immunostaining were present in fetal, RDS, and BPD lungs. In RDS, IGF\u20101 was present in alveolar epithelium and prominent in columnar and cuboidal airway epithelia. In BPD lungs, immunostaining was intensely increased in both airway and alveolar epithelia and in mesenchyme. The immunostaining index in bronchial epithelial cells and peribronchial myofibroblasts was significantly higher in BPD compared to RDS. IGF\u20101R expression was minimal in fetal lung and found mainly in mesenchyme. IGF\u20101R was increased in mesenchyme in RDS. In BPD it was especially increased in peribronchial and perialveolar mesenchyme. Immunostaining index for IGF\u20101R in epithelial cells and peribronchial myofibroblasts was increased in BPD compared to RDS. IGF\u20101 and IGF\u2010R expression is low during fetal development, but is acutely upregulated in RDS, and persists with further upregulation in BPD. Pediatr Pulmonol. 2004; 37:128\u2013136. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.10415","type":"journal-article","created":{"date-parts":[[2004,1,13]],"date-time":"2004-01-13T12:01:44Z","timestamp":1073995304000},"page":"128-136","source":"Crossref","is-referenced-by-count":69,"title":["Insulin\u2010like growth factor\u20101 (IGF\u20101) and IGF\u20101 receptor (IGF\u20101R) expression in human lung in RDS and BPD"],"prefix":"10.1002","volume":"37","author":[{"given":"Anne","family":"Chetty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sture","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrik","family":"Lassus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heber C.","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,1,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(98)70219-7"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.153.2.494"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-3782(98)00045-0"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199912000-00007"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.131.4.1858"},{"key":"e_1_2_1_7_2","first-page":"293","article-title":"Hyperoxic exposure of developing rat lung decreases tropoelastin mRNA levels that rebound postexposure","volume":"265","author":"Bruce MC","year":"1993","journal-title":"Am J Physiol"},{"key":"e_1_2_1_8_2","first-page":"123","article-title":"Structural and biochemical changes in rat lungs occurring during exposure to lethal and adaptive doses of oxygen","volume":"122","author":"Crapo JD","year":"1980","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(98)90280-5"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950090306"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.58.030196.000445"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000243402"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.48.030186.003445"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.11.3.8086167"},{"key":"e_1_2_1_15_2","first-page":"196","article-title":"Collagen deposition in autoimmune diseases: the expanding role of the fibroblast in fibrotic disease","volume":"114","author":"Leroy EC","year":"1985","journal-title":"Ciba Found Symp"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008480-199606000-00002"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.12.1.7529031"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.21.12254"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1997.3888"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200005000-00008"},{"key":"e_1_2_1_21_2","first-page":"526","volume-title":"The two\u2010way layout with replicates. 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