{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T12:13:28Z","timestamp":1774527208686,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,4,21]],"date-time":"2004-04-21T00:00:00Z","timestamp":1082505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Volutrauma and pulmonary inflammation are thought to be the most important predisposing factors of chronic lung disease (CLD), a major complication of prematurity. A new option in patient\u2010triggered ventilation (PTV), the volume guarantee (VG), a volume\u2010targeted ventilation, seems to be a promising approach in reducing the risk of CLD, by limiting lung inflammatory injury and volutrauma. Our aim was to evaluate lung inflammatory response in preterm infants with respiratory distress syndrome (RDS), mechanically ventilated with and without VG, as measured by proinflammatory cytokines (IL\u20106, IL\u20108, and TNF\u2010\u03b1) in tracheobronchial aspirate (TA) fluid. Fifty\u2010three preterm infants (GA\u2009=\u200925\u201332 weeks) with RDS were randomized at birth to be ventilated using pressure support ventilation (PSV) with VG (Vt\u2009=\u20095 ml\/kg) (n\u2009=\u200930) and without VG (n\u2009=\u200923) (Draeger Babylog 8000 Plus, 5.n). IL\u20106, IL\u20108, and TNF\u2010\u03b1 were determined by ELISA in TA samples on days 1, 3, and 7 of life. We observed a significant difference (ANOVA) in IL\u20108 and IL\u20106 levels on day 3 between the two groups (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), and an increasing significative trend in IL\u20108 values in PSV group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Mechanical ventilation lasted longer in the PSV group (12.3\u2009\u00b1\u20093 vs. 8.8\u2009\u00b1\u20093 days) (<jats:italic>P<\/jats:italic>\u2009=\u2009no significance). In conclusion, these preliminary data suggest a role for volume\u2010targeted ventilatory strategy in reducing acute inflammatory response in preterm infants with RDS. Further studies are required in order to define whether this ventilatory strategy prevents lung injury. Pediatr Pulmonol. 2004; 37:510\u2013514. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.10458","type":"journal-article","created":{"date-parts":[[2004,4,23]],"date-time":"2004-04-23T07:01:13Z","timestamp":1082703673000},"page":"510-514","source":"Crossref","is-referenced-by-count":99,"title":["Impact of targeted\u2010volume ventilation on lung inflammatory response in preterm infants with respiratory distress syndrome (RDS)"],"prefix":"10.1002","volume":"37","author":[{"given":"G.","family":"Lista","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Colnaghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Castoldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Cond\u00f2","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Reali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Compagnoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Mosca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,4,21]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004310100785"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1542\/peds.93.5.712","article-title":"Association of pulmonary inflammation and increased microvascular permeability during the development of BPD: a sequential analysis of inflammatory mediators in respiratory fluids of high risk preterm neonates","volume":"93","author":"Groneck P","year":"1994","journal-title":"Pediatrics"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199408000-00017"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.116.suppl_1.9S-a"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.105.1.112"},{"key":"e_1_2_1_7_2","first-page":"453","article-title":"Volume guarantee (VG) during pressure support ventilation (PSV) reduces the risk of barotrauma in preterm infants with respiratory distress syndrome (RDS)","volume":"71","author":"Lista G","year":"2000","journal-title":"Acta Biomed Arteneo Parmense"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.110.3.529"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199809000-00011"},{"key":"e_1_2_1_10_2","first-page":"1","article-title":"Patient\u2010ventilator interactions in new models of patient\u2010triggered ventilation","volume":"31","author":"Abubakar KM","year":"2001","journal-title":"Pediatr Pulmonol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.107.6.1323"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1152\/jappl.1989.66.5.2364","article-title":"Chest wall restriction limits high airway pressure\u2010induced injury in young rabbits","volume":"66","author":"Hernandez LA","year":"1989","journal-title":"J Appl Physiol"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199909000-00037"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.10458","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.10458","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T22:12:32Z","timestamp":1700172752000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.10458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4,21]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2004,6]]}},"alternative-id":["10.1002\/ppul.10458"],"URL":"https:\/\/doi.org\/10.1002\/ppul.10458","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,4,21]]}}}