{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T14:19:41Z","timestamp":1789913981061,"version":"4.0.1"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2001,4,30]],"date-time":"2001-04-30T00:00:00Z","timestamp":988588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2001,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to evaluate the ability of high\u2010resolution computerized tomography (HRCT) of the chest and chest x\u2010rays (CXR) to determine efficacy of inhaled recombinant human DNase (rhDNase) in cystic fibrosis (CF) patients younger than 5 years of age. A randomized, double\u2010blind, placebo\u2010controlled pilot study of 12 patients with CF younger than 5 years of age, attending the University of Michigan Cystic Fibrosis Center (Ann Arbor, MI) was conducted. The changes in the HRCT and CXR score from baseline to day 100 of therapy were assessed using a previously validated scoring system.<\/jats:p><jats:p>The mean changes of HRCT scores between the rhDNase and placebo groups were found to be significant at the 95% level, with mean change\u2009\u00b1\u2009\u2009SE mean of \u2212\u20091.00\u2009\u2009\u00b1\u2009\u20090.53 and 0.58\u2009\u2009\u00b1\u2009\u20090.24 for rhDNase and placebo groups, respectively (<jats:italic>P<\/jats:italic>\u2009\u2009=\u2009\u20090.02). The difference in CXR score was not significant between the two groups. An analysis was performed to relate HRCT subscores to CXR score; only thickening of the intra\u2010interlobular septae was significantly correlated with the total CXR score (r\u2009\u2009=\u2009\u2009\u2212\u20090.7, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). There was improvement in the parents' assessments of the patients' well\u2010being, with improvement in physical activity, decreased cough, sleep quality, and appetite in those subjects receiving rhDNase.<\/jats:p><jats:p>We conclude that the administration of rhDNase was associated with improvement in the HRCT scan in CF patients younger than 5 years of age. Findings indicate that HRCT of the chest is useful and sensitive in studying responses to therapy in patients with CF lung disease. To our knowledge, this is the first report of the use of HRCT to assess the effectiveness of a therapeutic modality in so young a CF patient population. Pediatr Pulmonol. 2001; 31:377\u2013382. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.1061","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T20:13:04Z","timestamp":1030306384000},"page":"377-382","source":"Crossref","is-referenced-by-count":80,"title":["Use of computerized tomography and chest X\u2010rays in evaluating efficacy of aerosolized recombinant human DNase in cystic fibrosis patients younger than age 5 years: A preliminary study*"],"prefix":"10.1002","volume":"31","author":[{"given":"Samya Z.","family":"Nasr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence R.","family":"Kuhns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall W.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin E.","family":"Hurwitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgiana M.","family":"Sanders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Strouse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,4,30]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"1126","volume-title":"Textbook of respiratory medicine","author":"Boat TF","year":"1988"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/142.5.1053"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.154.5.8912759"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.23.9188"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)92297-7"},{"key":"e_1_2_1_7_2","first-page":"3184","article-title":"Efficacy and safety of aerosolized recombinant human DNase in patients with cystic fibrosis","volume":"40","author":"DNase Clinical Research Consortium","year":"1992","journal-title":"Clin Res"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199409083311003"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(98)70055-1"},{"key":"e_1_2_1_10_2","volume-title":"Patient registry. 1997 annual data report","author":"Cystic Fibrosis Foundation","year":"1998"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-62-733-1"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950110112"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.179.3.2027992"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005382-199601110-00002"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.169.2.9242738"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.176.1.2353097"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.101.6.1071"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1990.02150360033014"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.160.3.8430539"},{"key":"e_1_2_1_20_2","unstructured":"GoodsittM diagnostic radiologist physicist unpublished data October 17 1997."},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.101.5.908"},{"key":"e_1_2_1_22_2","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1542\/peds.63.1.24","article-title":"The roentgenogram in cystic fibrosis: a new scoring system","volume":"63","author":"Brasfield D","year":"1979","journal-title":"Pediatrics"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.1061","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.1061","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T18:05:42Z","timestamp":1700417142000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.1061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,4,30]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,5]]}},"alternative-id":["10.1002\/ppul.1061"],"URL":"https:\/\/doi.org\/10.1002\/ppul.1061","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,4,30]]}}}