{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T17:47:05Z","timestamp":1768585625404,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2001,4,30]],"date-time":"2001-04-30T00:00:00Z","timestamp":988588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2001,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lobar atelectasis is a common complication of cystic fibrosis. The majority of cases respond to intravenous antibiotics and chest physiotherapy. In a subgroup of patients, atelectasis is resistant to medical therapy, and its persistence in the pediatric population is associated with a poor prognosis.<\/jats:p><jats:p>Bronchoscopic instillation of human recombinant DNase expanded atelectatic lobes in three children resistant to at least 2 weeks of medical therapy. This method of administration of DNase has been successful in resistant cases of lobar atelectasis in patients with chronic obstructive pulmonary disease, quadriplegia, and status asthmaticus. Purulent cystic fibrosis sputum has a very high DNA content, and DNA has been shown to become more pourable in vitro when treated with rhDNase.<\/jats:p><jats:p>Bronchoscopic instillation of rhDNase should be considered in cases of persistent lobar atelectasis unresponsive to medical therapy. Pediatr Pulmonol. 2001; 31:383\u2013388. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.1062","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T20:13:04Z","timestamp":1030306384000},"page":"383-388","source":"Crossref","is-referenced-by-count":36,"title":["Bronchoscopically administered recombinant human DNase for lobar atelectasis in cystic fibrosis*"],"prefix":"10.1002","volume":"31","author":[{"given":"Dubhfeasa M.","family":"Slattery","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Waltz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Denham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"O'Mahony","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Greally","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,4,30]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"821","article-title":"Treatment and prognosis of lobar and segmental atelectasis in cystic fibrosis","volume":"118","author":"Stern RC","year":"1978","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_1_3_2","first-page":"178","article-title":"Bronchial obstruction with lobar atelectasis and emphysema in cystic fibrosis of the pancreas","volume":"12","author":"Di Sant Agnese PA","year":"1953","journal-title":"Pediatrics"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0954-6111(94)90063-9"},{"key":"e_1_2_1_5_2","first-page":"971","article-title":"Acute lobar atelectasis: a prospective comparison of fiberoptic bronchoscopy and respiratory therapy","volume":"119","author":"Marini JJ","year":"1979","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_1_6_2","first-page":"193","article-title":"Evaluation of chronic atelectasis in children using chest computed tomography and bronchoscopy","volume":"37","author":"Wong KS","year":"1996","journal-title":"Chung Hua Min Kuo Hsiao Erh Ko I Hsueh Hui Tsa Chih"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/000992288502400703"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950160402"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.50.12.1319"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198602133140706"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1968.tb28997.x"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.99.6.1507"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199212313272708"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.8.3.207"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-8707(52)90017-8"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.8.3.195"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(87)90065-0"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.13.1.27"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.38.6.616"},{"key":"e_1_2_1_20_2","first-page":"156","article-title":"Pulmonary lavage in a patient in status asthmaticus receiving mechanical ventilation. 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