{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T05:57:26Z","timestamp":1774418246612,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2001,5,29]],"date-time":"2001-05-29T00:00:00Z","timestamp":991094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2001,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We hypothesized that during high\u2010frequency oscillatory ventilation (HFOV), a reduction of peak\u2010to\u2010peak oscillatory pressure along the endotracheal tube is maximal when respiratory system compliance is maximal. We made a mathematical model of the endotracheal tube and the respiratory system of a neonate suffering from idiopathic respiratory distress syndrome (IRDS). The model consisted of linear viscous and inertive elements, a non\u2010linear endotracheal tube resistance, and a non\u2010linear compliance allowing for alveolar recruitment and overdistention. Respiratory compliance was maximal at the transition between maximal recruitment and minimal overdistention. A new variable, the oscillatory pressure ratio (OPR), was defined as the ratio between peak\u2010to\u2010peak oscillatory pressures at the distal end and the proximal opening of the endotracheal tube, respectively. The respiratory variables of four patients were fed into the model, and the relationship between respiratory system compliance and OPR was determined.<\/jats:p><jats:p>OPR decreased as compliance increased, except for very low compliances below where 0.08 mL\u2009\u00b7\u2009cmH<jats:sub>2<\/jats:sub>O<jats:sup>\u22121<\/jats:sup>, and OPR increased with increasing compliance. The relationship between mean airway pressure <jats:italic>P\u0304<jats:sub>aw<\/jats:sub><\/jats:italic> and OPR revealed that the minimal OPR (range, 0.37\u20130.78) and maximal respiratory compliance coincided at the same <jats:italic>P\u0304<jats:sub>aw<\/jats:sub><\/jats:italic>. However, the relationship did depend on oscillation frequency, applied oscillatory pressure, and endotracheal tube resistance, parameters that may change during clinical application of HFOV. When 81 permutations of nominal and extreme respiratory variables were used in the model, the minimum OPR (0.60\u2009\u00b1\u20090.23) and maximum compliance coincided in all cases.<\/jats:p><jats:p>These model experiments support our hypothesis. The results indicate that the OPR may be a useful index to optimize lung expansion, where lung recruitment is maximal and overdistention minimal. In vivo tests will be needed to reveal the feasibility and reliability of such an index for biomedical and clinical application. Pediatr Pulmonol. 2001; 31:458\u2013463. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.1075","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T20:40:11Z","timestamp":1030308011000},"page":"458-463","source":"Crossref","is-referenced-by-count":27,"title":["Reduction of oscillatory pressure along the endotracheal tube is indicative for maximal respiratory compliance during high\u2010frequency oscillatory ventilation: A mathematical model study"],"prefix":"10.1002","volume":"31","author":[{"given":"H.R.","family":"van Genderingen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Versprille","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Leenhoven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.G.","family":"Markhorst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.J.","family":"van Vught","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.M.","family":"Heethaar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,5,29]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1542\/peds.98.6.1044","article-title":"The provo multicenter early high\u2010frequency oscillatory ventilation trial: improved pulmonary and clinical outcome in respiratory distress syndrome","volume":"98","author":"Gerstmann DR","year":"1996","journal-title":"Pediatrics"},{"key":"e_1_2_1_3_2","first-page":"21","volume-title":"Assisted ventilation of the neonate","author":"Harris TR","year":"1996"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1984.56.3.553"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198401000-00011"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199010000-00013"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950180408"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1980.tb07093.x"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199422091-00004"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00262890"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950040109"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1115\/1.3138523"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111061"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198704000-00001"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199111000-00019"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199601000-00019"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199422091-00002"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.1981.324725"},{"key":"e_1_2_1_19_2","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1152\/jappl.1988.64.4.1607","article-title":"Lung volume recruitment during high\u2010frequency oscillation in atelectasis\u2010prone rabbits","volume":"64","author":"Byford LJ","year":"1988","journal-title":"J Appl Physiol"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/137.5.1185"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.1075","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.1075","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T18:42:16Z","timestamp":1700419336000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.1075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,5,29]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2001,6]]}},"alternative-id":["10.1002\/ppul.1075"],"URL":"https:\/\/doi.org\/10.1002\/ppul.1075","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,5,29]]}}}