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However, exercise produced a greater rise in forced expiratory volume in 1 second (FEV<jats:sub>1<\/jats:sub>) than hyperventilation alone. Hyperventilation of cold dry air resulted in a period of refractoriness to a second stress of the same type. Refractoriness induced by exercise or hyperventilation of cold dry air may be the result of refractoriness of the trigger site in the large airways.<\/jats:p>","DOI":"10.1002\/ppul.1950010205","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T11:36:36Z","timestamp":1173180996000},"page":"80-84","source":"Crossref","is-referenced-by-count":3,"title":["Refractoriness to bronchoconstriction following hyperventilation with cold dry air"],"prefix":"10.1002","volume":"1","author":[{"given":"Manuel E.","family":"Soto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Schnall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis 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