{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T09:40:32Z","timestamp":1697881232299},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,10,20]],"date-time":"2005-10-20T00:00:00Z","timestamp":1129766400000},"content-version":"vor","delay-in-days":6928,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[1986,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pseudomonas cepacia, a significant pulmonary pathogen among children with cystic fibrosis (CF), often possesses an inducible \u03b2\u2010lactamase. The \u03b2\u2010lactamase isoelectric focusing pattern and \u03b2\u2010lactam susceptibility of CF and non\u2010CF isolates of P. cepacia were compared. Against all of the test strains, ceftazidime and piperacillin were more effective than aztreonam. More CF isolates were resistant to 8 \u03bcg\/ml of ceftazidime than non\u2010CF isolates. Isoelectric focusing of cefoxitin\u2010induced, cell\u2010free preparations of the CF isolates produced significantly more bands than comparable preparations of non\u2010CF isolates. Organisms producing a \u03b2\u2010lactamase band that focused in the pH range of 8.5 to 8.7 were significantly more resistant to 8 \u03bcg\/ml of ceftazidime than other isolates. The increased resistance of CF isolates of P. cepacia to ceftazidime may be the result of the production of a specific bacterial \u03b2\u2010lactamase.<\/jats:p>","DOI":"10.1002\/ppul.1950020609","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T12:14:57Z","timestamp":1173183297000},"page":"368-372","source":"Crossref","is-referenced-by-count":6,"title":["Differences in drug susceptibility between isolates of <i>pseudomonas cepacia<\/i> recovered from patients with cystic fibrosis and other sources and its relationship to beta\u2010lactamase focusing pattern"],"prefix":"10.1002","volume":"2","author":[{"given":"Stephen C.","family":"Aronoff","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauline H.","family":"Labrozzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,10,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/149.2.283"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(84)80993-2"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(85)80511-4"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(84)81094-X"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.25.2.279"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/15.5.545"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-94-1-55"},{"key":"e_1_2_1_9_2","first-page":"20","article-title":"Resistance of Pseudomonas species to betalactam antibiotics","volume":"129","author":"Bidwell JL","year":"1981","journal-title":"Scand J Infect Dis"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.17.3.355"},{"key":"e_1_2_1_11_2","first-page":"453","volume-title":"Manual of clinical microbiology","author":"Washington JA","year":"1980"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-88-1-169"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/146837a0"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2911(08)60376-8"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.15.6.792"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.23.6.918"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.27.4.455"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/13.1.15"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/12.4.363"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/2.2.115"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-76-2-455"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/15.6.665"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.25.3.382"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/148.2.316"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.27.3.393"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(83)80377-1"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/12.2.127"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(85)90259-1"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/12.suppl_A.331"},{"key":"e_1_2_1_30_2","unstructured":"GuerinS GuayR LetarteR andLevesqueRMultiple forms of Enterobacter cloaceae cephalosporinase gene products: role of regulatory sequences. 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