{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T01:03:42Z","timestamp":1774659822321,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,12,5]],"date-time":"2005-12-05T00:00:00Z","timestamp":1133740800000},"content-version":"vor","delay-in-days":6732,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[1987,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We examined the hypercarbic ventilatory responses (HVR) of 143 infants at risk for sudden infant death syndrome (SIDS) and 34 normal control infants. Sixty\u2010five of the atrisk infants had experienced apparent life\u2010threatening events (ALTE), and 78 were siblings of SIDS victims. Twenty\u2010three (35%) of the ALTE infants experienced subsequent apnea; one died of SIDS. Seven (9%) of the SIDS siblings experienced subsequent apnea; two ultimately died of SIDS. In the HVR studies, we measured tidal volume (V<jats:sub>T<\/jats:sub>), minute ventilation (V<jats:sub>E<\/jats:sub>), frequency of breathing (f), and end\u2010tidal P<jats:sub>CO<\/jats:sub><jats:sub>2<\/jats:sub> (P<jats:sub>ETCO<\/jats:sub><jats:sub>2<\/jats:sub>) at rest and while breathing 2% and 4% CO<jats:sub>2<\/jats:sub>. Mean HVR values for the ALTE, sibling, and control groups were all similar. The mean HVR values for those at\u2010risk infants who experienced subsequent apnea were not different from those who did not experience subsequent apnea. However, those infants experiencing subsequent apnea had higher mean V<jats:sub>T<\/jats:sub>\/kg values (P &lt; 0.01) and lower mean P<jats:sub>ETCO<\/jats:sub><jats:sub>2<\/jats:sub> values (P &lt; 0.001) than those who did not. The SIDS siblings had significantly lower resting V<jats:sub>T<\/jats:sub>\/kg values than either the near\u2010miss infants or normal controls (P &lt; 0.01).<\/jats:p><jats:p>We did not find depressed HVR values in infants at risk for SIDS. On the contrary, those infants who experienced subsequent apnea had evidence suggesting relative <jats:italic>hyper<\/jats:italic>ventilation. SIDS siblings had evidence suggesting relative <jats:italic>hypo<\/jats:italic>ventilation. These findings are interesting and thought\u2010provoking. However, HVR studies do not appear to be sensitive, specific, or appropriate for the general screening of infants at risk for SIDS.<\/jats:p>","DOI":"10.1002\/ppul.1950030406","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T12:08:44Z","timestamp":1173182924000},"page":"226-230","source":"Crossref","is-referenced-by-count":16,"title":["Hypercarbic ventilatory responses of infants at risk for SIDS"],"prefix":"10.1002","volume":"3","author":[{"given":"J. Michael","family":"Coleman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark C.","family":"Mammel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Reardon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J.","family":"Boros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,5]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"63","volume-title":"The Near\u2010Miss SIDS in Crib Death: The Sudden Infant Death Syndrome","author":"Guntheroth WG","year":"1982"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(84)81093-8"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.50.4.646"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197710062971403"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1093\/sleep\/3.3-4.351","article-title":"Waking and ventilatory responses during sleep in infants near\u2010miss for sudden infant death syndrome","volume":"3","author":"Ariagno R","year":"1980","journal-title":"Sleep."},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(85)80289-4"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198303000-00011"},{"key":"e_1_2_1_9_2","first-page":"363","article-title":"Ventilatory response to hypercapnia","volume":"1","author":"Rigatto H","year":"1977","journal-title":"Semin Perinatol."},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1152\/jappl.1972.33.2.252","article-title":"Brodsky J, et al. Changes in tidal volume, frequency, and ventilation induced by their measurement","volume":"33","author":"Gilbert R","year":"1972","journal-title":"J Appl Physiol."},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(74)90454-5"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-197909000-00006"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1152\/jappl.1983.54.6.1482","article-title":"Transient ventilatory response to CO2 as a function of sleep state in full term infants","volume":"54","author":"Anderson JV","year":"1983","journal-title":"J Appl Physiol."},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1542\/peds.70.3.447","article-title":"Chloral hydrate and the carbon dioxide chemoreceptor response: A study of puppies and infants","volume":"70","author":"Lees MH","year":"1982","journal-title":"Pediatrics."},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1542\/peds.50.2.202","article-title":"Periodic breathing and apnea in preterm infants: I. Evidence for hypoventilation possibly due to central respiratory depression","volume":"50","author":"Rigatto H","year":"1972","journal-title":"Pediatrics."},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1152\/jappl.1981.50.6.1313","article-title":"Diminished hypoxic ventilatory responses in near\u2010miss sudden infant death syndrome","volume":"50","author":"Hunt CE","year":"1981","journal-title":"J Appl Physiol."},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198115050-00011"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1542\/peds.66.2.205","article-title":"Sudden infant death syndrome: Sleep apnea and respiration in subsequent siblings","volume":"66","author":"Hoppenbrouwers T","year":"1980","journal-title":"Pediatrics."},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.epirev.a036228"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.1950030406","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.1950030406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T01:09:57Z","timestamp":1697850597000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.1950030406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,7]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1987,7]]}},"alternative-id":["10.1002\/ppul.1950030406"],"URL":"https:\/\/doi.org\/10.1002\/ppul.1950030406","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,7]]}}}