{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T20:19:20Z","timestamp":1778703560168,"version":"3.51.4"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,12,5]],"date-time":"2005-12-05T00:00:00Z","timestamp":1133740800000},"content-version":"vor","delay-in-days":6732,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[1987,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A study was designed to determine the sensitivity and specificity of a cold air bronchial provocation test. A total of 18 children with asthma (mean age 12 years) and 18 normal children (mean age 14 years) were studied. The cold air challenge consisted of a 4 min period of isocapnic hyperventilation of subfreezing air (mean temperature \u2212 15\u00b0C). In\u2010Induced response in forced expiratory volume in 1 sec (FEV<jats:sub>1<\/jats:sub>) expressed as a percentage of predicted normal values was obtained at 4, 6, and 8 min post\u2010challenge. The average response to the cold air was a 27% decrease of FEV<jats:sub>1<\/jats:sub> in asthmatics, which was significantly different from that of the normal children, who showed no statistically significant drop. In both the asthmatic and normal groups, the maximal drop in FEV<jats:sub>1<\/jats:sub> had occurred by the time measurements 4 min post\u2010challenge had been made. At that time, the smallest overlap was observed between normal and asthmatic children. This suggests that the fourth minute postchallenge can be chosen as a cut\u2010off time to distinguish normal from asthmatic children. Considering a decrease of FEV<jats:sub>1<\/jats:sub> greater than 10% as a positive test, the sensitivity of the cold air challenge was 95% and the specificity was 89%.<\/jats:p>","DOI":"10.1002\/ppul.1950030410","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T12:08:44Z","timestamp":1173182924000},"page":"251-254","source":"Crossref","is-referenced-by-count":21,"title":["Cold air challenge in children with asthma"],"prefix":"10.1002","volume":"3","author":[{"given":"J.","family":"Reisman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Mappa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"de Benedictis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"McLaughlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Levison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,5]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(85)80009-3"},{"key":"e_1_2_1_3_2","first-page":"621","article-title":"Airway responsiveness to cold air and hyperpnea in normal subjects and in those with hay fever and asthma","volume":"121","author":"Deal EC","year":"1980","journal-title":"Am Rev Respir Dis."},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1542\/peds.72.4.503","article-title":"Cold air inhalation challenge in the diagnosis of asthma in children","volume":"72","author":"McLaughlin FJ","year":"1983","journal-title":"Pediatrics."},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(84)80539-9"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198405000-00016"},{"key":"e_1_2_1_7_2","first-page":"879","article-title":"Standards of pulmonary function in children","volume":"99","author":"Weng TR","year":"1969","journal-title":"Am Rev Respir Dis."},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(80)80039-4"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.113.2.272"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(83)90521-3"},{"key":"e_1_2_1_11_2","volume-title":"Airway challenge using isocapneic hyperventilation","author":"O'Byrne PM","year":"1983"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.1950030410","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.1950030410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T01:10:17Z","timestamp":1697850617000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.1950030410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,7]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1987,7]]}},"alternative-id":["10.1002\/ppul.1950030410"],"URL":"https:\/\/doi.org\/10.1002\/ppul.1950030410","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,7]]}}}