{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T05:13:20Z","timestamp":1771046000448,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T00:00:00Z","timestamp":1134345600000},"content-version":"vor","delay-in-days":6555,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[1988,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Since persistent pulmonary hypertension of the newborn (PPHN) often occurs as a life\u2010threatening illness, it would be advantageous to identify the highest\u2010risk infants within the first 24 hours of life so that transfer to centers with extracorporeal membrane oxygenation (ECMO) or high\u2010frequency ventilation can be facilitated. Fifty\u2010three infants with PPHN were evaluated retrospectively. A multivariate discriminant analysis of risk factors determined that lowest pH, critical Pa<jats:sub>CO<\/jats:sub><jats:sub>2<\/jats:sub>, highest inspiratory pressure (PI), maximum ventilator rate, and 5\u2010minute Apgar score were significantly different between the 35 survivors (66%) and the 18 infants (34%) who had died when examined with in the first 24 hours of life. A clinical scoring system was designed based on these five criteria, which predicted outcome accurately in 93% of infants. A logistic regression analysis was performed as a check on these results and found that lowest pH, critical Pa<jats:sub>CO<\/jats:sub><jats:sub>2<\/jats:sub>, and PI predicted outcome with great accuracy. These results suggest that the use of these scoring systems within the first 24 hours of age may help predict outcome in infants with PPHN.<\/jats:p>","DOI":"10.1002\/ppul.1950050103","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T13:08:39Z","timestamp":1173186519000},"page":"6-9","source":"Crossref","is-referenced-by-count":15,"title":["Predicting survival in infants with persistent pulmonary hypertension of the newborn"],"prefix":"10.1002","volume":"5","author":[{"given":"Jonathan M.","family":"Davis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan R.","family":"Spitzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Cox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William W.","family":"Fox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,12]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"87A","article-title":"\u201ePFC\u201d\ufe01 syndrome (persistence of the fetal circulation)","volume":"40","author":"Gersony WM","year":"1969","journal-title":"Circulation [Suppl]."},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/000992287701600407"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(83)80573-3"},{"key":"e_1_2_1_5_2","unstructured":"FoxWW. Mechanical ventilation in the management of persistent pulmonary hypertension of the neonate (PPHN).Proceedings of the 83rd Ross Conference on Cardiovascular Sequelae of Asphyxia in the Newborn.1982:102."},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1542\/peds.72.6.872","article-title":"Use of extracorporeal membrane oxygenation for respiratory failure in term infants","volume":"72","author":"Kirkpatrick BV","year":"1983","journal-title":"Pediatr."},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1542\/peds.76.4.479","article-title":"Extracorporeal circulation in neonatal respiratory failureA prospective randomized study","volume":"76","author":"Bartlett RH","year":"1985","journal-title":"Pediatr."},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(84)80136-5"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)81239-6"},{"key":"e_1_2_1_10_2","first-page":"457A","article-title":"Reduced incidence of bronchopulmonary dysplasia with early initiation of high frequency oscillation for persistent pulmonary hypertension of the newborn.","volume":"21","author":"Kohelet D","year":"1987","journal-title":"Pediatr Res."},{"key":"e_1_2_1_11_2","first-page":"375A","article-title":"Right\u2010sided brain lesions in infants following unilateral carotid ligation for extracorporeal membrane oxygenation.","volume":"21","author":"Schumacher RE","year":"1987","journal-title":"Pediatr Res."},{"key":"e_1_2_1_12_2","first-page":"369A","article-title":"Outcome of 100 infants treated with extacorporeal membrane oxygenation (ECMO).","volume":"21","author":"Miller MK","year":"1987","journal-title":"Pediatr Res."},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1542\/peds.76.4.622","article-title":"Extracorporeal membrane oxygenation and play the winner rule","volume":"76","author":"Paneth N","year":"1985","journal-title":"Pediatr."},{"key":"e_1_2_1_14_2","first-page":"360A","article-title":"Survival in infants with persistent pulmonary hypertension without extracorporeal membrane oxygenation.","volume":"21","author":"Dworetz AR","year":"1987","journal-title":"Pediatr Res."},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(73)90426-0"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(84)80257-2"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(86)80188-9"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.1950050103","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.1950050103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T00:01:23Z","timestamp":1695772883000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.1950050103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1988,1]]}},"alternative-id":["10.1002\/ppul.1950050103"],"URL":"https:\/\/doi.org\/10.1002\/ppul.1950050103","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,1]]}}}