{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T13:49:32Z","timestamp":1760622572388},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,10,20]],"date-time":"2005-10-20T00:00:00Z","timestamp":1129766400000},"content-version":"vor","delay-in-days":6136,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[1989,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We evaluated the effects of an 8\u2010week aerobic training (1 hr, three times a week) on physical performance of ten patients with cystic fibrosis (CF) (median age, 12.5 yr; range 11.1\u201315.3 yr), with mild airway obstruction (FEV<jats:sub>1<\/jats:sub> = 77 \u00b1 22% pred.), and ten healthy age\u2010matched children (CONTR) (median age, 12.7 yr; range 12.2\u201315.2 yr). Physical performance was tested with maximal incremental (MAX) and submaximal (SMAX) (fixed workload of 1.7 W\/kg during 6 min) exercise tests on a cycle ergometer. These and standard spirometric and anthropometric measurements were performed at the beginning and end of a period with usual daily activity and one with the training program. The kinetics of ventilatory parameters at the onset and end of SMAX were displayed by fitting data on oxygen uptake and minute ventilation by monoexponential curves (least\u2010squares method). At the start and the end of the training period, all children were timed for endurance run to voluntary exhaustion and for sprinting through an obstacle course. A pattern of relative hyperventilation during SMAX and of poor performance in endurance and obstacle runs were evident at the start of the training period in patients with CF. The effects of training on MAX and SMAX were small and partial; the improvement in field test performances was significant only for CF and could be attributed to improvement of skill and motivation. <jats:bold>Pediatr Pilmonol. 1989; 7:145\u2013152<\/jats:bold>.<\/jats:p>","DOI":"10.1002\/ppul.1950070306","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T14:05:12Z","timestamp":1173189912000},"page":"145-152","source":"Crossref","is-referenced-by-count":21,"title":["Exercise tolerance and effects of training in young patients with cystic fibrosis and mild airway obstruction"],"prefix":"10.1002","volume":"7","author":[{"given":"C.","family":"Braggion","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Cornacchia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Miano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Schena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Verlato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Mastellay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,10,20]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"217","article-title":"Cardiorespiratory adaptations to exercise in cystic fibrosis","volume":"126","author":"Cerny FJ","year":"1982","journal-title":"Am Rev Respir Dis."},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000413448"},{"key":"e_1_2_1_4_2","first-page":"341","article-title":"The role of nutritional status, airway obstruction, hypoxia and abnormalities in serum lipid composition in limiting exercise tolerance in children with cystic fibrosis","volume":"15","author":"Coates AL","year":"1979","journal-title":"Bull Europ Physiopathol Resp."},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950020505"},{"key":"e_1_2_1_6_2","volume-title":"Exercise Testing in Children","author":"Godfrey S","year":"1974"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.61.4.362"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.57.8.587"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0007-0971(87)90109-4"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.92.2.273"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","unstructured":"StanghelleJK MichalsenH SkybergD. Five\u2010year follow\u2010up of pulmonary function and peak oxygen uptake in 16\u2010year\u2010old boys with cystic fibrosis with special regard to the influence of regular physical exercise.Int J Sports Med.1988; Suppl. 9:19\u201324.","DOI":"10.1055\/s-2007-1025057"},{"key":"e_1_2_1_12_2","first-page":"80","article-title":"Effects of a swimming program on children with cystic fibrosis","volume":"140","author":"Edlung LD","year":"1986","journal-title":"Am J Dis Child."},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)91440-9"},{"key":"e_1_2_1_14_2","first-page":"853","article-title":"Ventilatory muscle endurance training in normal subjects and patients with cystic fibrosis","volume":"116","author":"Keens TG","year":"1977","journal-title":"Am Rev Respir 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chronic airway obstruction\u2014Are they effective?","volume":"67","author":"Jones DT","year":"1985","journal-title":"Eur J Respir Dis."},{"key":"e_1_2_1_24_2","first-page":"86","article-title":"Training and the respiratory system\u2014Therapy for asthma and other obstructive lung diseases?","volume":"34","author":"Shepard RJ","year":"1982","journal-title":"Ann Clin Res"},{"key":"e_1_2_1_25_2","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-71404-7","volume-title":"Die Praxis der Sportmedizin in der Kinder\u2010heilkunde","author":"Bar\u2010Or O","year":"1986"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80135-8"},{"key":"e_1_2_1_27_2","first-page":"18","article-title":"Exercise testing in children with congenital heart disease","volume":"13","author":"Mocellin 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