{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T06:18:00Z","timestamp":1773469080982,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,10,20]],"date-time":"2005-10-20T00:00:00Z","timestamp":1129766400000},"content-version":"vor","delay-in-days":5771,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[1990,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Continuous negative pressure ventilation utilizes subatmospheric pressure around the thorax to improve oxygenation. It has not been routinely used since the mid\u20101970s. We treated 37 infants with the combination of continuous negative pressure (CNP) and intermittent mandatory ventilation (IMV), after failing to attain a Pa<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tex2gif-inf-1.gif\" xlink:title=\"urn:x-wiley:87556863:media:PPUL1950080407:tex2gif-inf-1\"\/> of \u226550 torr on IMV alone. Lung diseases included pulmonary interstitial emphysema (PIE), respiratory distress syndrome (RDS), and pulmonary artery hypertension (PAH) due either to meconium aspiration syndrome (MAS) or other causes (non\u2010MAS). All infants had evidence of severe parenchymal pulmonary disease, or pulmonary artery hypertension resulting in persistent hypoxemia and hypotension. In the PIE group, CNP was started later in the course of the disease, and both positive pressure and oxygen were maintained for a longer period. The group of infants with non\u2010MAS PAH required CNP and positive pressure ventilation for the shortest period of time. The infants with PIE also had a greater incidence of bronchopulmonary dysplasia (BPD) and intraventricular hemorrhage (IVH). In addition, three patients with PIE died. In the non\u2010MAS patients with PAH, no complications and no deaths occurred. The response to CNP was a rapid improvement in oxygenation in all groups with the greatest increase of Pa<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tex2gif-inf-3.gif\" xlink:title=\"urn:x-wiley:87556863:media:PPUL1950080407:tex2gif-inf-3\"\/> in the non\u2010MAS PAH infants: from 30 torr prior to the initiation of CNP to 140 torr within 30 minutes. No significant changes in pH or Pa<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tex2gif-inf-5.gif\" xlink:title=\"urn:x-wiley:87556863:media:PPUL1950080407:tex2gif-inf-5\"\/> occurred in any group. Significant decreases in ventilator rate, mean airway pressure (P<jats:styled-content>aw<\/jats:styled-content>) and FI<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tex2gif-inf-7.gif\" xlink:title=\"urn:x-wiley:87556863:media:PPUL1950080407:tex2gif-inf-7\"\/> in peak inspiratory pressure were possible by 12 hours of CNP. CNP and Paw were decreased from \u22125 cm H<jats:sub>2<\/jats:sub>O and 12.8 cm H<jats:sub>2<\/jats:sub>O prior to initiation of CNP to \u22121 cm H<jats:sub>2<\/jats:sub>O and 5.0 cm H<jats:sub>2<\/jats:sub>O at 72 hours of treatment. FI<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tex2gif-inf-13.gif\" xlink:title=\"urn:x-wiley:87556863:media:PPUL1950080407:tex2gif-inf-13\"\/> at 72 hours was decreased to a mean of 0.57. Combined CNP and IMV ventilator therapy improved oxygenation with lessened P<jats:styled-content>aw<\/jats:styled-content> in infants with refractory hypoxemia due to MAS and PAH and in larger infants with RDS. While we cannot advocate the routine use of CNP, it would appear to have a role in the management of infants who have failed conventional ventilator therapy. Pediatr Pulmonol 1990; 8:245\u2010253.<\/jats:p>","DOI":"10.1002\/ppul.1950080407","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T14:38:40Z","timestamp":1173191920000},"page":"245-253","source":"Crossref","is-referenced-by-count":20,"title":["Reintroduction of continuous negative pressure ventilation in neonates: Two\u2010year experience"],"prefix":"10.1002","volume":"8","author":[{"given":"William G.","family":"Cvetnic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Douglas","family":"Cunningham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack H.","family":"Sills","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis","family":"Gluck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,10,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(70)80160-3"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1542\/peds.39.5.740","article-title":"A controlled trial of management of respiratory distress syndrome in a body\u2010enclosing respirator: I. 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