{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T17:21:51Z","timestamp":1771262511596,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,11,11]],"date-time":"2005-11-11T00:00:00Z","timestamp":1131667200000},"content-version":"vor","delay-in-days":5428,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[1991,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Albuterol is a specific beta\u20102 agonist that has been reported to be effective in treating infants and children with bronchospastic pulmonary disease. The use of oral albuterol has not been investigated in patients with bronchopulmonary dysplasia (BPD). Thirty premature infants were randomized to receive oral albuterol (0.15 mg\/kg\/dose q8h) or a volume\u2010 and color\u2010matched placebo (D5\/W). Pulmonary functions were evaluated at baseline and at 48 and 96 hours after entry to the study. The study was also designed for crossover from placebo to albuterol or albuterol to caffeine in the event that the infant's total pulmonary resistance did not improve at the time of the 48 hour pulmonary function evaluation. Heart rate and respiratory rate showed a statistically significant but clinically unimportant increase in the albuterol\u2010treated infants. There were no significant differences noted in systolic or diastolic blood pressure. Percent improvement in the pulmonary function indices were calculated from baseline to 48 hours and from baseline to 96 hours for the placebo and albuterol\u2010treated groups. The results indicate that at 48 hours there were statistically significant improvements in total resistance (14.5%), inspiratory resistance (10.8%), and expiratory resistance (12.9%) in the albuterol\u2010treated infants as compared to the spontaneous deterioration of the same values by 25%, 81%, and 11%, respectively, in the placebo\u2010treated infants. In conclusion, oral albuterol therapy of 48 hours duration improved pulmonary resistance without major cardiovascular side effects in ventilator\u2010dependent premature infants. Pediatr Pulmonol 1991; 10:183\u2010190.<\/jats:p>","DOI":"10.1002\/ppul.1950100309","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T15:37:40Z","timestamp":1173195460000},"page":"183-190","source":"Crossref","is-referenced-by-count":19,"title":["A Randomized Placebo\u2010Controlled Study to Evaluate the Effects of Oral Albuterol on Pulmonary Mechanics in Ventilator\u2010Dependent Infants at Risk of Developing BPD"],"prefix":"10.1002","volume":"10","author":[{"given":"John L.","family":"Stefano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinod K.","family":"Bhutani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William W.","family":"Fox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1542\/peds.71.1.13","article-title":"Dexamethasone and albutamol in the treatment of acute wheezing in infants","volume":"71","author":"Tal A","year":"1983","journal-title":"Pediatrics."},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.53.7.532"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.61.10.1020"},{"key":"e_1_2_1_5_2","first-page":"694","article-title":"Bronchopulmonary dysplasia. 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