{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T17:52:29Z","timestamp":1698342749730},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,5]],"date-time":"2005-12-05T00:00:00Z","timestamp":1133740800000},"content-version":"vor","delay-in-days":5452,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[1991,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of this study was to investigate spontaneous changes in bronchial responsiveness to inhaled histamine over a period of 18 months. The first measurements in 495 subjects, 7 to 16 years of age, were made in 1986. Bronchial hyperresponsiveness (BHR), i.e., PC\u201020 FEV<jats:sub>1<\/jats:sub> \u2a7d 8.0 mg\/mL, was found in 79 (16%) individuals, of whom 28 (35%) had symptoms of asthma. Twenty asthmatic and 42 non\u2010asthmatic subjects who had BHR (78%) were re\u2010examined 18 months later. The asthmatics had a modest change in BHR, while in the non\u2010asthmatics bronchial response to inhaled histamine and exercise was significantly decreased. In twenty\u2010two subjects (36%) bronchial response was within the normal range; of these 18 were non\u2010asthmatic. Six asthmatics (30%) and two non\u2010asthmatics (5%) had an increased BHR at follow\u2010up. Two subjects (5%) developed symptoms of asthma by the time of follow\u2010up, with an unchanged degree of BHR. Sex, age, atopic symptoms, and viral respiratory infections at the first examination were unrelated to changes in bronchial responsiveness. However, changes of BHR in the non\u2010asthmatic subjects were significantly correlated to changes in bronchial response to exercise. Although spontaneous changes in bronchial responsiveness occur in asthmatic, as well as non\u2010asthmatic subjects, asthmatics persistently have hyperresponsive airways. Development of asthma was found to occur among subjects with persistent BHR. Pediatr Pulmonol. 1991; 11 :22\u201028. <\/jats:p>","DOI":"10.1002\/ppul.1950110105","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T15:32:45Z","timestamp":1173195165000},"page":"22-28","source":"Crossref","is-referenced-by-count":9,"title":["Spontaneous changes in bronchial responsiveness in children and adolescents: An 18\u2010month follow\u2010up"],"prefix":"10.1002","volume":"11","author":[{"given":"V.","family":"Backer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Groth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Dirksen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,5]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1987.tb02015.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.83.5.751"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1977.tb01448.x"},{"key":"e_1_2_1_5_2","first-page":"121","article-title":"Modification of bronchial hyperreactivity during pollen season in children allergic to grass","volume":"58","author":"Barbato A","year":"1987","journal-title":"Ann Allergy."},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(90)90181-3"},{"key":"e_1_2_1_7_2","first-page":"295","article-title":"Airway hyperreactivity and peripheral airway dysfunction in influenza A infection","volume":"118","author":"Little JW","year":"1978","journal-title":"Am Rev Respir Dis."},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(88)90930-X"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.91.5.671"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1989.tb02387.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(84)90279-3"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/isbn.978-3-318-04125-5","volume-title":"Lung function in children and adolescents. 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