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Pulmonary mechanics were measured by the passive expiratory flow technique. Total respiratory system compliance (Crs) gradually improved as RDS resolved. However, a significant decrease in mean Crs was associated with the development of a clinically detectable PDA, ranging from 1.51 \u00b1 0.21 to 0.90 \u00b1 0.08 mL\/cmH<jats:sub>2<\/jats:sub>O\/m (<jats:italic>P<\/jats:italic> &lt; 0.05). We also noted an increase in mean Crs, from 0.90 \u00b1 0.08 to 1.49 \u00b1 0.21 mL\/cmH<jats:sub>2<\/jats:sub>O\/m (<jats:italic>P<\/jats:italic> &lt; 0.05), after successful treatment of a PDA with indomethacin. Total respiratory system resistance (Rrs) did not change. We conclude that a clinically significant PDA is associated with a decreased Crs and that successful treatment of a PDA with indomethacin is associated with an improvement in lung compliance. These findings imply that the development of a clinically detectable PDA and its subsequent treatment complicates the interpretation of pulmonary mechanics data in VLBW infants with RDS.<\/jats:p>","DOI":"10.1002\/ppul.1950110214","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T15:29:12Z","timestamp":1173194952000},"page":"161-165","source":"Crossref","is-referenced-by-count":11,"title":["Effects of a clinically detectable PDA on pulmonary mechanics measures in VLBW infants with RDS"],"prefix":"10.1002","volume":"11","author":[{"given":"Michael J.","family":"Balsan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith G.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert D.","family":"Guthrie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,5]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950040109"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950040110"},{"key":"e_1_2_1_4_2","first-page":"233","volume-title":"Assisted Ventilation of the Neonate","author":"Cunningham MD","year":"1988"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950050104"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(83)80202-9"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(88)80702-9"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950080403"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80917-2"},{"key":"e_1_2_1_10_2","first-page":"96","article-title":"Lung compliance in newborns with patent ductus arteriosus before and after surgical ligation","volume":"1980","author":"Gerhardt T","journal-title":"Biol Neonate."},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.80.6.698"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/143.2.236"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(88)80391-3"},{"key":"e_1_2_1_14_2","first-page":"519","volume-title":"Neonatal Pulmonary Care","author":"Baylen BG","year":"1986"},{"key":"e_1_2_1_15_2","first-page":"552","article-title":"Passive respiratory mechanics in newborns and children","volume":"129","author":"Le Souef PN","year":"1984","journal-title":"Am Rev Respir Dis."},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950090409"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/141.5_Pt_1.1127"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1152\/jappl.1987.63.6.2315","article-title":"Respiratory effects of a patent ductus arteriosus in premature newborn lambs","volume":"63","author":"Perez Fontan JJ","year":"1987","journal-title":"J Appl Physiol."},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199006000-00027"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/142.2.413"},{"key":"e_1_2_1_21_2","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1152\/jappl.1983.55.1.169","article-title":"Permeability of premature lamb lungs to protein and the effect of surfactant on that permeability","volume":"55","author":"Jobe A","year":"1983","journal-title":"J Appl Physiol."},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112992"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81660-9"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(82)80247-3"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.1950110214","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.1950110214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T03:19:43Z","timestamp":1698031183000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.1950110214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,1]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1991,1]]}},"alternative-id":["10.1002\/ppul.1950110214"],"URL":"https:\/\/doi.org\/10.1002\/ppul.1950110214","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,1]]}}}