{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:04:29Z","timestamp":1785769469737,"version":"3.56.0"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,10,21]],"date-time":"2005-10-21T00:00:00Z","timestamp":1129852800000},"content-version":"vor","delay-in-days":4982,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[1992,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To determine the extent of pulmonary dysfunction following primary closure of an abdominal wall defect, we obtained pulmonary function tests (PFT) in 11 newborn infants with gastroschisis and 6 with large omphaloceles admitted to a newborn ICU in a children's hospital. Patients were 1 to 30 days of age at the time of the PFT; all required endotracheal intubation and mechanical ventilation for operative procedures or for postoperative ventilatory support. Full\u2010term infants (n = 21) undergoing minor surgical procedures provided comparative measurements. Flow\u2010volume curves were obtained with manual inflation of the lungs followed by forced deflation using negative pressure, or by passive expiration, under sedation and pharmacologic paralysis. Deflation flow\u2010volume curves gave measurements of forced vital capacity (FVC) and maximal expiratory flow at 25% of vital capacity from residual volume (MEF<jats:sub>25<\/jats:sub>). Modified passive mechanics technique gave passive expiratory curves that provided measurements of respiratory system compliance (Crs) and resistance (Rrs). Tests were done: within 48 h (period A), 3\u20137 days (period B), and 8\u201330 days after surgical repair (period C). Pulmonary function testing after nebulized 0.1% isoetharine (a bronchodilator), to test for bronchial reactivity, began midway during the study period in 15 patients. Preoperative and postoperative tests were obtained in 5 patients. Closure of an abdominal wall defect decreased FVC, Crs, and MEF<jats:sub>25<\/jats:sub> by up to 50% of normal, reference values after surgery (<jats:italic>P<\/jats:italic> &lt; 0.05). FVC and MEF<jats:sub>25<\/jats:sub> approached values of normal infants' by 4 weeks, whereas Crs remained 50% lower. Bronchodilators improved FVC by 21% and MEF<jats:sub>25<\/jats:sub> by up to 48% during the first week of life (both, <jats:italic>P<\/jats:italic> &lt; 0.05), but MEF<jats:sub>25<\/jats:sub>\/FVC was not significantly altered, reflecting the opening of new lung units with no effect on upstream conductance. Bronchodilators may benefit babies who have respiratory difficulties following closure of abdominal wall defects.<\/jats:p>","DOI":"10.1002\/ppul.1950120309","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T16:41:45Z","timestamp":1173199305000},"page":"174-180","source":"Crossref","is-referenced-by-count":18,"title":["Pulmonary dysfunction after primary closure of an abdominal wall defect and its improvement with bronchodilators"],"prefix":"10.1002","volume":"12","author":[{"given":"Don K.","family":"Nakayama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Mutich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etsuro K.","family":"Motoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,10,21]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(79)80128-1"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198002000-00002"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198807000-00012"},{"key":"e_1_2_1_5_2","first-page":"52","article-title":"Ventilatory support and primary closure of gastroschisis","volume":"91","author":"Bower RJ","year":"1982","journal-title":"Surgery"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/136.1.50"},{"key":"e_1_2_1_7_2","first-page":"552","article-title":"Passive respiratory mechanics in newborns and children","volume":"129","author":"LeSouef PN","year":"1984","journal-title":"Am Rev Respir Dis."},{"key":"e_1_2_1_8_2","first-page":"740","volume-title":"Pediatric Surgery","author":"Schuster SR","year":"1986"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1967.22.1.95"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(87)80739-X"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(83)80010-4"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198908000-00027"},{"key":"e_1_2_1_13_2","first-page":"146","volume-title":"Assisted Ventilation of the Neonate","author":"Fox WW","year":"1988"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(84)80605-8"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1972.106.3.366"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950110109"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.1950120309","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.1950120309","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T04:21:32Z","timestamp":1698121292000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.1950120309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,3]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1992,3]]}},"alternative-id":["10.1002\/ppul.1950120309"],"URL":"https:\/\/doi.org\/10.1002\/ppul.1950120309","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,3]]}}}