{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T04:42:23Z","timestamp":1785818543093,"version":"3.56.0"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,11,4]],"date-time":"2005-11-04T00:00:00Z","timestamp":1131062400000},"content-version":"vor","delay-in-days":4874,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[1992,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Seventy\u2010eight longitudinal four\u2010channel recordings of heart rate, thoracic impedance, nasal thermistry, and pulse oximetry were performed on 26 asymptomatic premature infants (gestational age, 29.9 \u00b1 1.58 weeks; birth weight, 1,753 \u00b1 226 grams; postconceptional age, 34.3 \u00b1 2.0 weeks; postnatal age, 4.41 \u00b1 2.40 weeks; all values mean \u00b1 SD). Tracings were scored for central and obstructive apnea, bradycardia, periodic breathing, apnea density, and prolonged apnea. The studies demonstrated 585 episodes (7.41\/recording) of oxyhemoglobin desaturation with &lt; 80% and 1,193 episodes (15.1\/recording) desaturation with &lt; 90%. Recordings had a mean of 16.1 episodes of central apnea, 3.04 episodes of obstructive apnea, and 2.34 episodes of bradycardia. Periodic breathing and short obstructive apneas correlated significantly with the total number of oxyhemoglobin desaturations of &lt; 80% and 90%. Episodes of prolonged apnea were seen in 20 of 78 recordings. In the latter a significantly higher number of total desaturations &lt; 90%), desaturations &lt; 80% and 90% in association with apnea and with bradycardia, longer desaturations, desaturations during sleep, and isolated bradycardia were observed. Variations in heart rate, thoracic impedance, nasal air flow, and pulse oximetry are associated with episodes of oxyhemoglobin desaturation in asymptomatic premature infants. These infants, although asymptomatic, may be at risk for impaired tissue oxygenation. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.1950130305","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T17:05:27Z","timestamp":1173200727000},"page":"151-154","source":"Crossref","is-referenced-by-count":13,"title":["Prolonged apnea and oxyhemoglobin desaturation in asymptomatic premature infants"],"prefix":"10.1002","volume":"13","author":[{"given":"Michael L.","family":"Spear","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John L.","family":"Stefano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan R.","family":"Spitzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,4]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1542\/peds.84.5.785","article-title":"Periodic breathing in preterm infants: Incidence and charac\u2010teristics","volume":"84","author":"Glotzbach SF","year":"1989","journal-title":"Pediatrics."},{"key":"e_1_2_1_3_2","first-page":"54","article-title":"Apnea, transient episodes of bradycardia, and periodic breathing in preterm infants","volume":"144","author":"Hodgman JE","year":"1990","journal-title":"Am J Dis Child."},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-999370"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(77)80691-4"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(86)80685-0"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(64)80185-2"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1542\/peds.74.5.763","article-title":"Sequential 22\u2010hour profiles of breathing patterns and heart rate in 110 full\u2010term infants during their first 6 months of life","volume":"74","author":"Richards JM","year":"1984","journal-title":"Pediatrics."},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1542\/peds.70.6.844","article-title":"Prolonged apnea and cardiac arrhythmias in infants discharged from neonatal intensive care units: Failure to predict an increased risk for sudden infant death syndrome","volume":"70","author":"Southall DP","year":"1982","journal-title":"Pediatrics."},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1542\/peds.50.2.202","article-title":"Periodic breathing and apnea in preterm infants. 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