{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:31:42Z","timestamp":1787679102238,"version":"build-2784847793"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,10,21]],"date-time":"2005-10-21T00:00:00Z","timestamp":1129852800000},"content-version":"vor","delay-in-days":4798,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[1992,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To determine the effect of bovine surfactant (SF\u2010RI 1, Alveofact) administered during the first hour following birth to very premature infants [gestational age (GA). 25\u201030 weeks] in a multicenter, controlled trial. <jats:bold>Hypothesis<\/jats:bold>: Survival without bronchopulmonary dysplasia (BPD; definition: ventilator dependency or FiO<jats:sub>2<\/jats:sub> &gt; 0.3 during spontaneous respiration) at day 28 is increased in surfactant\u2010treated infants (sequential analysis). <jats:bold>Patients and methods<\/jats:bold>: Thirty\u2010four infants [GA 28.0 \u00b1 1.5 SD weeks, birth weight (BW), 1,048 \u00b1 299 g] received 50 mg\/kg BW surfactant, whereas 35 infants (GA, 27.6 \u00b1 1.5 weeks, BW 969 \u00b1 269 g) served as controls. Retreatment with surfactant (up to three identical doses) 12\u201024 hours after the previous dose was permitted if FiO<jats:sub>2<\/jats:sub> was &gt; 0.5. <jats:bold>Results<\/jats:bold>: Survival without BPD was significantly higher in surfactant treated infants (26\/34) compared to controls (14\/35; P=0.003). but in the incidence of pulmonary air leaks, patent ductus arteriosus, intracranial hemorrhage, and nosocomial infections they were not different. <jats:bold>Conclusion<\/jats:bold>: Bovine surfactant treatment improves survival without BPD in very premature infants at risk for neonatal respiratory distress syndrome (RDS). \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.1950140103","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T17:56:12Z","timestamp":1173203772000},"page":"4-9","source":"Crossref","is-referenced-by-count":27,"title":["Early treatment of respiratory distress syndrome with bovine surfactant in very preterm infants: A multicenter controlled clinical trial"],"prefix":"10.1002","volume":"14","author":[{"given":"L.","family":"Gortner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Bartmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Pohlandt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Bernsau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Porz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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